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Query: NC_016911:771916:775663 Rickettsia rickettsii str. Hauke chromosome, complete genome

Start: 775663, End: 776925, Length: 1263

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016914:772025:7757727757727770341263Rickettsia rickettsii str. Hino chromosome, complete genomehypothetical protein0761
NC_016909:771542:7752897752897765511263Rickettsia rickettsii str. Arizona chromosome, complete genomehypothetical protein0761
NC_010263:771901:7756487756487769101263Rickettsia rickettsii str. Iowa, complete genomehypothetical protein0761
NC_012730:131445:1352271352271364891263Rickettsia peacockii str. Rustic, complete genomehypothetical protein0734
NC_016050:771752:7755297755297766561128Rickettsia japonica YH, complete genomehypothetical protein5e-158557
NC_015866:767790:7714537714537725801128Rickettsia heilongjiangensis 054 chromosome, complete genomehypothetical protein4e-156551
NC_016929:474000:4854554854554873291875Rickettsia canadensis str. CA410 chromosome, complete genomehypothetical protein2e-70266
NC_009879:475500:4864344864344880141581Rickettsia canadensis str. McKiel, complete genomehypothetical protein2e-70266
NC_017058:671000:6821666821666832511086Rickettsia australis str. Cutlack chromosome, complete genomehypothetical protein5e-46185
NC_009881:724269:7311897311897322171029Rickettsia akari str. Hartford, complete genomehypothetical protein7e-45181