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Query: NC_016911:771916:773247 Rickettsia rickettsii str. Hauke chromosome, complete genome

Start: 773247, End: 773561, Length: 315

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016914:772025:773356773356773670315Rickettsia rickettsii str. Hino chromosome, complete genomehypothetical protein9e-55211
NC_016909:771542:772873772873773187315Rickettsia rickettsii str. Arizona chromosome, complete genomehypothetical protein9e-55211
NC_010263:771901:773232773232773546315Rickettsia rickettsii str. Iowa, complete genomehypothetical protein9e-55211
NC_012730:131445:132776132776133090315Rickettsia peacockii str. Rustic, complete genomehypothetical protein6e-54209
NC_016050:771752:773083773083773397315Rickettsia japonica YH, complete genomehypothetical protein3e-52203
NC_015866:767790:769121769121769435315Rickettsia heilongjiangensis 054 chromosome, complete genomehypothetical protein3e-52203
NC_016929:474000:489053489053489376324Rickettsia canadensis str. CA410 chromosome, complete genomeDNA repair protein RecO1e-41167
NC_009879:475500:489730489730490062333Rickettsia canadensis str. McKiel, complete genomeDNA repair protein RecO1e-40165
NC_017058:671000:684962684962685303342Rickettsia australis str. Cutlack chromosome, complete genomehypothetical protein5e-40162
NC_009881:724269:729152729152729469318Rickettsia akari str. Hartford, complete genomehypothetical protein2e-37154
NC_006142:683000:684357684357684692336Rickettsia typhi str. Wilmington, complete genomerickettsial conserved hypothetical protein6e-37152
NC_017066:683000:684369684369684704336Rickettsia typhi str. TH1527 chromosome, complete genomehypothetical protein6e-37152
NC_017056:678450:678450678450678770321Rickettsia prowazekii str. BuV67-CWPP chromosome, complete genomehypothetical protein6e-36149
NC_017051:674000:676616676616676936321Rickettsia prowazekii str. Dachau chromosome, complete genomehypothetical protein6e-36149
NC_017050:676000:678473678473678793321Rickettsia prowazekii str. Katsinyian chromosome, complete genomehypothetical protein6e-36149
NC_017049:675261:676604676604676924321Rickettsia prowazekii str. Chernikova chromosome, complete genomehypothetical protein6e-36149
NC_017048:1018000:102064610206461020966321Rickettsia prowazekii str. GvV257 chromosome, complete genomehypothetical protein6e-36149
NC_000963:676000:678477678477678797321Rickettsia prowazekii str. Madrid E, complete genomehypothetical protein6e-36149
NC_007940:322948:333000333000333422423Rickettsia bellii RML369-C, complete genomehypothetical protein3e-27120
NC_009883:1197500:121438412143841214704321Rickettsia bellii OSU 85-389, complete genomehypothetical protein4e-27119