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Query: NC_016911:278415:282169 Rickettsia rickettsii str. Hauke chromosome, complete genome

Start: 282169, End: 282459, Length: 291

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016915:278000:281629281629282135507Rickettsia rickettsii str. Hlp#2 chromosome, complete genometransporter9e-41165
NC_010263:278463:282168282168282835668Rickettsia rickettsii str. Iowa, complete genome1e-40164
NC_016914:278500:282302282302282592291Rickettsia rickettsii str. Hino chromosome, complete genometransporter2e-40164
NC_016913:859931:886599886599886889291Rickettsia rickettsii str. Brazil chromosome, complete genometransporter2e-40164
NC_016909:278327:282081282081282371291Rickettsia rickettsii str. Arizona chromosome, complete genometransporter2e-40164
NC_016908:278457:282208282208282498291Rickettsia rickettsii str. Colombia chromosome, complete genometransporter2e-40164
NC_017065:274165:282563282563283339777Rickettsia slovaca str. D-CWPP chromosome, complete genometransporter3e-40163
NC_017043:990395:999413999413999859447Rickettsia montanensis str. OSU 85-930 chromosome, complete genometransporter8e-35145
NC_017058:1152361:116610011661001166732633Rickettsia australis str. Cutlack chromosome, complete genometransporter1e-31134
NC_012633:276500:2797642797642809011138Rickettsia africae ESF-5, complete genome7e-30129
NC_015866:274550:283320283320283727408Rickettsia heilongjiangensis 054 chromosome, complete genometransporter7e-22102
NC_015866:274550:283724283724283846123Rickettsia heilongjiangensis 054 chromosome, complete genometransporter5e-0753.1