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Query: NC_016911:13826:27811 Rickettsia rickettsii str. Hauke chromosome, complete genome

Start: 27811, End: 28044, Length: 234

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016930:11721:260992609926332234Rickettsia philipii str. 364D chromosome, complete genomehypothetical protein4e-28123
NC_016914:13826:278992789928132234Rickettsia rickettsii str. Hino chromosome, complete genomehypothetical protein4e-28123
NC_016913:1134000:114089111408911141124234Rickettsia rickettsii str. Brazil chromosome, complete genomehypothetical protein4e-28123
NC_016909:16465:278142781428047234Rickettsia rickettsii str. Arizona chromosome, complete genomehypothetical protein4e-28123
NC_016908:13826:278222782228055234Rickettsia rickettsii str. Colombia chromosome, complete genomehypothetical protein4e-28123
NC_009882:13826:278202782028053234Rickettsia rickettsii str. 'Sheila Smith', complete genomeTetratricopeptide repeat-containing protein4e-28123
NC_016915:13927:278592785928092234Rickettsia rickettsii str. Hlp#2 chromosome, complete genomehypothetical protein7e-28122
NC_010263:13826:279442794428045102Rickettsia rickettsii str. Iowa, complete genomehypothetical protein6e-1269.7