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Query: NC_016911:13826:19320 Rickettsia rickettsii str. Hauke chromosome, complete genome

Start: 19320, End: 19466, Length: 147

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016915:13927:194231942319671249Rickettsia rickettsii str. Hlp#2 chromosome, complete genomehypothetical protein2e-2097.4
NC_010263:13826:193211932119467147Rickettsia rickettsii str. Iowa, complete genomehypothetical protein3e-2097.4
NC_009882:13826:193211932119467147Rickettsia rickettsii str. 'Sheila Smith', complete genomehypothetical protein3e-2097.4
NC_016908:13826:193211932119467147Rickettsia rickettsii str. Colombia chromosome, complete genomehypothetical protein3e-2097.4
NC_016909:16465:193231932319469147Rickettsia rickettsii str. Arizona chromosome, complete genomehypothetical protein3e-2097.4
NC_016913:1134000:114939211493921149538147Rickettsia rickettsii str. Brazil chromosome, complete genomehypothetical protein3e-2097.4
NC_016914:13826:193211932119467147Rickettsia rickettsii str. Hino chromosome, complete genomehypothetical protein3e-2097.4
NC_017065:13188:196261962619772147Rickettsia slovaca str. D-CWPP chromosome, complete genomehypothetical protein3e-2097.4
NC_017044:15697:195111951119759249Rickettsia parkeri str. Portsmouth chromosome, complete genomeComEC/Rec2 family protein2e-2097.4
NC_003103:12114:164331643316681249Rickettsia conorii str. Malish 7, complete genomehypothetical protein4e-2096.7
NC_012633:12000:164561645616704249Rickettsia africae ESF-5, complete genomeComEC/Rec2 family protein2e-1994.4
NC_016931:38350:410754107541302228Rickettsia massiliae str. AZT80 chromosome, complete genomehypothetical protein1e-1168.6
NC_017042:77363:931349313493460327Rickettsia rhipicephali str. 3-7-female6-CWPP chromosome, completeComEC/Rec2-like protein3e-1167