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Query: NC_016911:13826:18262 Rickettsia rickettsii str. Hauke chromosome, complete genome

Start: 18262, End: 18486, Length: 225

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010263:13826:182631826318487225Rickettsia rickettsii str. Iowa, complete genomehypothetical protein2e-37154
NC_003103:12114:153791537915603225Rickettsia conorii str. Malish 7, complete genomehypothetical protein2e-37154
NC_009882:13826:182631826318487225Rickettsia rickettsii str. 'Sheila Smith', complete genomehypothetical protein2e-37154
NC_016908:13826:182631826318469207Rickettsia rickettsii str. Colombia chromosome, complete genomehypothetical protein3e-34143
NC_016909:16465:182651826518471207Rickettsia rickettsii str. Arizona chromosome, complete genomehypothetical protein3e-34143
NC_016913:1134000:115039011503901150596207Rickettsia rickettsii str. Brazil chromosome, complete genomehypothetical protein3e-34143
NC_016914:13826:182631826318469207Rickettsia rickettsii str. Hino chromosome, complete genomehypothetical protein3e-34143
NC_017065:13188:185681856818774207Rickettsia slovaca str. D-CWPP chromosome, complete genomehypothetical protein3e-34143
NC_015866:14071:184951849518938444Rickettsia heilongjiangensis 054 chromosome, complete genomeComEC/Rec2-like protein8e-33138
NC_016915:13927:183641836418549186Rickettsia rickettsii str. Hlp#2 chromosome, complete genomehypothetical protein2e-30130
NC_017028:109811:124858124858125052195Candidatus Rickettsia amblyommii str. GAT-30V chromosome, completehypothetical protein6e-30129
NC_017042:77363:934669346694428963Rickettsia rhipicephali str. 3-7-female6-CWPP chromosome, completeComEC/Rec2-like protein2e-28124
NC_017044:15697:184701847018694225Rickettsia parkeri str. Portsmouth chromosome, complete genomehypothetical protein3e-26116
NC_016930:11721:179631796318115153Rickettsia philipii str. 364D chromosome, complete genomehypothetical protein8e-1992.4
NC_017043:735150:737804737804737962159Rickettsia montanensis str. OSU 85-930 chromosome, complete genomehypothetical protein2e-1271.2