Pre_GI: BLASTP Hits

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Query: NC_016911:13826:13826 Rickettsia rickettsii str. Hauke chromosome, complete genome

Start: 13826, End: 14749, Length: 924

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016914:13826:138261382614749924Rickettsia rickettsii str. Hino chromosome, complete genomehypothetical protein5e-167587
NC_016913:1134000:115411011541101155033924Rickettsia rickettsii str. Brazil chromosome, complete genomehypothetical protein5e-167587
NC_016908:13826:138261382614749924Rickettsia rickettsii str. Colombia chromosome, complete genomehypothetical protein5e-167587
NC_009882:13826:138261382614749924Rickettsia rickettsii str. 'Sheila Smith', complete genomehypothetical protein5e-167587
NC_010263:13826:138261382614749924Rickettsia rickettsii str. Iowa, complete genomehypothetical protein5e-167587
NC_016930:11721:135271352714450924Rickettsia philipii str. 364D chromosome, complete genomehypothetical protein1e-166585
NC_016915:13927:139271392714850924Rickettsia rickettsii str. Hlp#2 chromosome, complete genomehypothetical protein3e-166584
NC_017065:13188:142011420115124924Rickettsia slovaca str. D-CWPP chromosome, complete genomehypothetical protein2e-165581
NC_016639:13188:142011420115124924Rickettsia slovaca 13-B chromosome, complete genomehypothetical protein2e-165581
NC_015866:14071:140711407114994924Rickettsia heilongjiangensis 054 chromosome, complete genomehypothetical protein1e-164578