Pre_GI: BLASTP Hits

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Query: NC_016909:1136210:1151519 Rickettsia rickettsii str. Arizona chromosome, complete genome

Start: 1151519, End: 1151821, Length: 303

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016930:1154500:117051311705131170815303Rickettsia philipii str. 364D chromosome, complete genomebeta-lactamase OXA-182e-46184
NC_016914:1136700:115200911520091152311303Rickettsia rickettsii str. Hino chromosome, complete genomebeta-lactamase OXA-182e-46184
NC_016913:24000:287702877029072303Rickettsia rickettsii str. Brazil chromosome, complete genomebeta-lactamase OXA-182e-46184
NC_016911:1136584:115189311518931152195303Rickettsia rickettsii str. Hauke chromosome, complete genomebeta-lactamase OXA-182e-46184
NC_016908:1136082:115138911513891151691303Rickettsia rickettsii str. Colombia chromosome, complete genomebeta-lactamase OXA-182e-46184
NC_009882:1123709:113968411396841139986303Rickettsia rickettsii str. 'Sheila Smith', complete genomehypothetical protein2e-46184
NC_010263:1135932:115124111512411151543303Rickettsia rickettsii str. Iowa, complete genomebeta-lactamase OXA-18 precursor2e-46184
NC_003103:1133806:114982511498251150127303Rickettsia conorii str. Malish 7, complete genomesimilarity to beta-lactamase7e-45178
NC_012633:1145500:115983911598391160552714Rickettsia africae ESF-5, complete genome3e-44176
NC_017028:1348865:136607913660791366381303Candidatus Rickettsia amblyommii str. GAT-30V chromosome, completebeta-lactamase2e-41167
NC_007109:1335037:135414913541491354949801Rickettsia felis URRWXCal2, complete genomeBeta-lactamase Class D3e-36150
NC_009900:1220082:123723712372371237482246Rickettsia massiliae MTU5, complete genome3e-34143
NC_015866:1144958:116407011640701164324255Rickettsia heilongjiangensis 054 chromosome, complete genomebeta-lactamase OXA-184e-34143
NC_007940:97949:122469122469123269801Rickettsia bellii RML369-C, complete genomeClass D beta-lactamase1e-31134
NC_017065:1144500:115894111589411159120180Rickettsia slovaca str. D-CWPP chromosome, complete genomebeta-lactamase OXA-188e-28122
NC_015376:1185000:119773711977371198543807Burkholderia gladioli BSR3 chromosome chromosome 2, completeBeta-lactamase3e-0960.5