Pre_GI: BLASTP Hits

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Query: NC_016908:278457:299307 Rickettsia rickettsii str. Colombia chromosome, complete genome

Start: 299307, End: 299567, Length: 261

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016915:278000:298951298951299211261Rickettsia rickettsii str. Hlp#2 chromosome, complete genomeprotein RelE4e-36149
NC_016913:859931:869530869530869790261Rickettsia rickettsii str. Brazil chromosome, complete genomeprotein RelE4e-36149
NC_016930:293245:296521296521296781261Rickettsia philipii str. 364D chromosome, complete genomeprotein RelE5e-36149
NC_017043:990395:101636710163671016627261Rickettsia montanensis str. OSU 85-930 chromosome, complete genomeputative toxin of toxin-antitoxin (TA) system StbD8e-34142
NC_014830:3275474:329548332954833295749267Intrasporangium calvum DSM 43043 chromosome, complete genomeaddiction module toxin, Txe/YoeB family4e-2096.7
NC_014355:1865003:191589519158951916158264Candidatus Nitrospira defluvii, complete genomeTxe/YoeB family addiction module toxin3e-1993.6
NC_008340:2034810:204044820404482040711264Alkalilimnicola ehrlichei MLHE-1, complete genomeaddiction module toxin, Txe/YoeB family9e-1992
NC_014364:2322269:235394723539472354207261Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeaddiction module toxin, Txe/YoeB family4e-1889.7
NC_019902:1061432:109353010935301093793264Thioalkalivibrio nitratireducens DSM 14787, complete genomeaddiction module toxin, Txe/YoeB family6e-1786.3
NC_015581:1043394:104986110498611050124264Thioalkalimicrobium cyclicum ALM1 chromosome, complete genomeaddiction module toxin, Txe/YoeB family3e-1683.6