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Query: NC_016908:278457:299054 Rickettsia rickettsii str. Colombia chromosome, complete genome

Start: 299054, End: 299296, Length: 243

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016930:293245:296268296268296510243Rickettsia philipii str. 364D chromosome, complete genomeprotein RelB2e-40164
NC_016915:278000:298698298698298940243Rickettsia rickettsii str. Hlp#2 chromosome, complete genomeprotein RelB2e-40164
NC_016913:859931:869801869801870043243Rickettsia rickettsii str. Brazil chromosome, complete genomeprotein RelB2e-40164
NC_017043:990395:101611410161141016356243Rickettsia montanensis str. OSU 85-930 chromosome, complete genomeantitoxin of toxin-antitoxin (TA) system StbD6e-39159
NC_008340:2034810:204070820407082040950243Alkalilimnicola ehrlichei MLHE-1, complete genomeprevent-host-death family protein2e-1891.3
NC_019902:1061432:109329110932911093533243Thioalkalivibrio nitratireducens DSM 14787, complete genomeputative antitoxin of toxin-antitoxin stability system5e-1889.7
NC_014830:3275474:329574632957463295991246Intrasporangium calvum DSM 43043 chromosome, complete genomeprevent-host-death family protein6e-1682.8
NC_015581:1043394:105012910501291050371243Thioalkalimicrobium cyclicum ALM1 chromosome, complete genomeprevent-host-death family protein6e-1682.8
NC_014355:1865003:191615519161551916397243Candidatus Nitrospira defluvii, complete genomeaxe/YefM family addiction module antitoxin1e-1582
NC_014364:2322269:235370523537052353947243Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeprevent-host-death family protein4e-1580.1
NC_007777:3000941:301791130179113018168258Frankia sp. CcI3, complete genomePrevent-host-death protein1e-0652