Pre_GI: BLASTP Hits

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Query: NC_016908:278457:296031 Rickettsia rickettsii str. Colombia chromosome, complete genome

Start: 296031, End: 296303, Length: 273

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016930:293245:293245293245293517273Rickettsia philipii str. 364D chromosome, complete genomehypothetical protein5e-47186
NC_016915:278000:295678295678295950273Rickettsia rickettsii str. Hlp#2 chromosome, complete genomehypothetical protein5e-47186
NC_016913:859931:872794872794873066273Rickettsia rickettsii str. Brazil chromosome, complete genomehypothetical protein5e-47186
NC_016911:278415:295992295992296264273Rickettsia rickettsii str. Hauke chromosome, complete genomehypothetical protein5e-47186
NC_016909:278327:295904295904296176273Rickettsia rickettsii str. Arizona chromosome, complete genomehypothetical protein5e-47186
NC_009882:278384:295966295966296238273Rickettsia rickettsii str. 'Sheila Smith', complete genomehypothetical protein5e-47186
NC_010263:278463:296039296039296311273Rickettsia rickettsii str. Iowa, complete genomehypothetical protein5e-47186
NC_016639:274157:296908296908297180273Rickettsia slovaca 13-B chromosome, complete genomehypothetical protein1e-45181
NC_017065:274165:296916296916297188273Rickettsia slovaca str. D-CWPP chromosome, complete genomehypothetical protein1e-45181
NC_016931:269537:288866288866289138273Rickettsia massiliae str. AZT80 chromosome, complete genomehypothetical protein3e-45180
NC_015866:274550:297439297439297708270Rickettsia heilongjiangensis 054 chromosome, complete genomehypothetical protein4e-45179
NC_017043:990395:101309210130921013364273Rickettsia montanensis str. OSU 85-930 chromosome, complete genomehypothetical protein4e-45179
NC_009879:260000:278483278483278755273Rickettsia canadensis str. McKiel, complete genomehypothetical protein1e-42171
NC_009881:283500:298188298188298469282Rickettsia akari str. Hartford, complete genomehypothetical protein2e-40164
NC_017066:262839:264785264785265054270Rickettsia typhi str. TH1527 chromosome, complete genomehypothetical protein5e-39159
NC_006142:262825:264771264771265040270Rickettsia typhi str. Wilmington, complete genomerickettsial conserved hypothetical protein5e-39159