Pre_GI: BLASTP Hits

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Query: NC_016908:278457:293557 Rickettsia rickettsii str. Colombia chromosome, complete genome

Start: 293557, End: 293796, Length: 240

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016914:278500:293651293651293890240Rickettsia rickettsii str. Hino chromosome, complete genomehypothetical protein3e-26117
NC_016913:859931:875301875301875540240Rickettsia rickettsii str. Brazil chromosome, complete genomehypothetical protein3e-26117
NC_016911:278415:293518293518293757240Rickettsia rickettsii str. Hauke chromosome, complete genomehypothetical protein3e-26117
NC_016909:278327:293430293430293669240Rickettsia rickettsii str. Arizona chromosome, complete genomehypothetical protein3e-26117
NC_010263:278463:293565293565293804240Rickettsia rickettsii str. Iowa, complete genomehypothetical protein3e-26117
NC_009882:278384:293486293486293725240Rickettsia rickettsii str. 'Sheila Smith', complete genomehypothetical protein1e-25114
NC_015866:274550:2941982941982954211224Rickettsia heilongjiangensis 054 chromosome, complete genomehypothetical protein7e-1785.9
NC_017043:990395:101044110104411011076636Rickettsia montanensis str. OSU 85-930 chromosome, complete genomehypothetical protein7e-1785.9
NC_012633:276500:291728291728292120393Rickettsia africae ESF-5, complete genomehypothetical protein2e-1477.4
NC_017044:278500:293755293755294009255Rickettsia parkeri str. Portsmouth chromosome, complete genomehypothetical protein1e-1375.1
NC_017058:1152361:115451311545131154956444Rickettsia australis str. Cutlack chromosome, complete genomehypothetical protein3e-1063.9
NC_009881:283500:295270295270295749480Rickettsia akari str. Hartford, complete genomehypothetical protein6e-0856.2