Pre_GI: BLASTP Hits

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Query: NC_016908:278457:292958 Rickettsia rickettsii str. Colombia chromosome, complete genome

Start: 292958, End: 293386, Length: 429

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016914:278500:293052293052293480429Rickettsia rickettsii str. Hino chromosome, complete genomehypothetical protein2e-79293
NC_016913:859931:875711875711876139429Rickettsia rickettsii str. Brazil chromosome, complete genomehypothetical protein2e-79293
NC_016911:278415:292919292919293347429Rickettsia rickettsii str. Hauke chromosome, complete genomehypothetical protein2e-79293
NC_016909:278327:292831292831293259429Rickettsia rickettsii str. Arizona chromosome, complete genomehypothetical protein2e-79293
NC_009882:278384:292887292887293315429Rickettsia rickettsii str. 'Sheila Smith', complete genomehypothetical protein2e-79293
NC_010263:278463:292966292966293394429Rickettsia rickettsii str. Iowa, complete genomehypothetical protein2e-79293
NC_016915:278000:292604292604293032429Rickettsia rickettsii str. Hlp#2 chromosome, complete genomehypothetical protein1e-78291
NC_015866:274550:2941982941982954211224Rickettsia heilongjiangensis 054 chromosome, complete genomehypothetical protein1e-63241
NC_017043:990395:101010110101011010433333Rickettsia montanensis str. OSU 85-930 chromosome, complete genomehypothetical protein3e-21100
NC_017065:274165:294177294177294311135Rickettsia slovaca str. D-CWPP chromosome, complete genomeputative ankyrin repeat protein5e-1786.3
NC_016639:274157:294169294169294303135Rickettsia slovaca 13-B chromosome, complete genomeputative ankyrin repeat protein5e-1786.3
NC_012633:276500:291057291057291338282Rickettsia africae ESF-5, complete genomeAnkyrin repeat protein3e-1270.5
NC_016931:269537:285709285709285870162Rickettsia massiliae str. AZT80 chromosome, complete genomehypothetical protein5e-1063.2
NC_017058:1152361:115493711549371155341405Rickettsia australis str. Cutlack chromosome, complete genomehypothetical protein3e-0960.5
NC_010830:1836984:1842930184293018476874758Candidatus Amoebophilus asiaticus 5a2, complete genomehypothetical protein5e-0649.7