Pre_GI: BLASTP Hits

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Query: NC_016908:278457:291455 Rickettsia rickettsii str. Colombia chromosome, complete genome

Start: 291455, End: 291598, Length: 144

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016915:278000:291101291101291244144Rickettsia rickettsii str. Hlp#2 chromosome, complete genomehypothetical protein4e-2097.1
NC_017065:274165:292252292252292374123Rickettsia slovaca str. D-CWPP chromosome, complete genomenucleotidyltransferase domain-containing protein1e-1581.6
NC_016639:274157:292244292244292366123Rickettsia slovaca 13-B chromosome, complete genomenucleotidyltransferase domain-containing protein1e-1581.6
NC_015866:274550:292715292715292837123Rickettsia heilongjiangensis 054 chromosome, complete genomehypothetical protein1e-1581.6
NC_016931:269537:284219284219284464246Rickettsia massiliae str. AZT80 chromosome, complete genomehypothetical protein1e-1478.2