Pre_GI: BLASTP Hits

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Query: NC_016908:278457:285477 Rickettsia rickettsii str. Colombia chromosome, complete genome

Start: 285477, End: 285920, Length: 444

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016913:859931:883177883177883620444Rickettsia rickettsii str. Brazil chromosome, complete genomehypothetical protein4e-71266
NC_016911:278415:285438285438285881444Rickettsia rickettsii str. Hauke chromosome, complete genomehypothetical protein4e-71266
NC_016909:278327:285350285350285793444Rickettsia rickettsii str. Arizona chromosome, complete genomehypothetical protein4e-71266
NC_009882:278384:285406285406285849444Rickettsia rickettsii str. 'Sheila Smith', complete genomehypothetical protein4e-71266
NC_010263:278463:285485285485285928444Rickettsia rickettsii str. Iowa, complete genomehypothetical protein4e-71266
NC_016915:278000:285120285120285566447Rickettsia rickettsii str. Hlp#2 chromosome, complete genomehypothetical protein1e-69261
NC_012730:293634:304918304918305334417Rickettsia peacockii str. Rustic, complete genomehypothetical protein1e-61234
NC_016639:274157:286280286280286696417Rickettsia slovaca 13-B chromosome, complete genomehypothetical protein3e-61233
NC_017065:274165:286288286288286704417Rickettsia slovaca str. D-CWPP chromosome, complete genomehypothetical protein3e-61233
NC_017044:278500:285605285605286021417Rickettsia parkeri str. Portsmouth chromosome, complete genomehypothetical protein2e-61233
NC_016931:269537:278315278315278746432Rickettsia massiliae str. AZT80 chromosome, complete genomehypothetical protein8e-61231
NC_012633:276500:283495283495283911417Rickettsia africae ESF-5, complete genomehypothetical protein2e-60230
NC_003103:266013:281122281122281538417Rickettsia conorii str. Malish 7, complete genomehypothetical protein5e-60229
NC_015866:274550:286802286802287218417Rickettsia heilongjiangensis 054 chromosome, complete genomehypothetical protein7e-58222
NC_017043:990395:100273410027341003150417Rickettsia montanensis str. OSU 85-930 chromosome, complete genomehypothetical protein7e-58222
NC_017058:1152361:116309611630961163374279Rickettsia australis str. Cutlack chromosome, complete genomehypothetical protein6e-25112
NC_016929:258500:268281268281268433153Rickettsia canadensis str. CA410 chromosome, complete genomehypothetical protein2e-0754.7
NC_009881:283500:287754287754287915162Rickettsia akari str. Hartford, complete genomehypothetical protein6e-0649.7