Pre_GI: BLASTP Hits

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Query: NC_016908:278457:282948 Rickettsia rickettsii str. Colombia chromosome, complete genome

Start: 282948, End: 283067, Length: 120

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010263:278463:282935282935283075141Rickettsia rickettsii str. Iowa, complete genomehypothetical protein2e-1477.4
NC_016915:278000:282591282591282710120Rickettsia rickettsii str. Hlp#2 chromosome, complete genomehypothetical protein3e-1477.4
NC_016914:278500:283042283042283161120Rickettsia rickettsii str. Hino chromosome, complete genomehypothetical protein3e-1477.4
NC_016913:859931:886030886030886149120Rickettsia rickettsii str. Brazil chromosome, complete genomehypothetical protein3e-1477.4
NC_016911:278415:282909282909283028120Rickettsia rickettsii str. Hauke chromosome, complete genomehypothetical protein3e-1477.4
NC_016909:278327:282821282821282940120Rickettsia rickettsii str. Arizona chromosome, complete genomehypothetical protein3e-1477.4
NC_009882:278384:282877282877282996120Rickettsia rickettsii str. 'Sheila Smith', complete genomehypothetical protein3e-1477.4
NC_016639:274157:283766283766283906141Rickettsia slovaca 13-B chromosome, complete genomehypothetical protein4e-1476.6
NC_017065:274165:283774283774283914141Rickettsia slovaca str. D-CWPP chromosome, complete genomehypothetical protein4e-1476.6
NC_017044:278500:283089283089283256168Rickettsia parkeri str. Portsmouth chromosome, complete genomehypothetical protein2e-1374.3
NC_017043:990395:100021810002181000358141Rickettsia montanensis str. OSU 85-930 chromosome, complete genomehypothetical protein3e-1373.9
NC_015866:274550:284287284287284427141Rickettsia heilongjiangensis 054 chromosome, complete genomehypothetical protein5e-1270.1
NC_017058:1152361:116590911659091166067159Rickettsia australis str. Cutlack chromosome, complete genomehypothetical protein1e-1168.6
NC_016931:269537:275802275802275996195Rickettsia massiliae str. AZT80 chromosome, complete genomehypothetical protein7e-0959.3
NC_009881:283500:284970284970285086117Rickettsia akari str. Hartford, complete genomepeptide deformylase8e-0752.4