Pre_GI: BLASTP Hits

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Query: NC_016908:278457:281994 Rickettsia rickettsii str. Colombia chromosome, complete genome

Start: 281994, End: 282236, Length: 243

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016914:278500:282088282088282330243Rickettsia rickettsii str. Hino chromosome, complete genometransporter3e-27120
NC_016913:859931:886861886861887103243Rickettsia rickettsii str. Brazil chromosome, complete genometransporter3e-27120
NC_016911:278415:281955281955282197243Rickettsia rickettsii str. Hauke chromosome, complete genometransporter3e-27120
NC_016909:278327:281867281867282109243Rickettsia rickettsii str. Arizona chromosome, complete genometransporter3e-27120
NC_009882:278384:281923281923282165243Rickettsia rickettsii str. 'Sheila Smith', complete genomeTransporter3e-27120
NC_016915:278000:281629281629282135507Rickettsia rickettsii str. Hlp#2 chromosome, complete genometransporter5e-1992.8
NC_017065:274165:282563282563283339777Rickettsia slovaca str. D-CWPP chromosome, complete genometransporter2e-1787.8
NC_012633:276500:2797642797642809011138Rickettsia africae ESF-5, complete genome3e-1787.4
NC_015866:274550:283320283320283727408Rickettsia heilongjiangensis 054 chromosome, complete genometransporter1e-1685.5