Pre_GI: BLASTP Hits

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Query: NC_016908:13826:18572 Rickettsia rickettsii str. Colombia chromosome, complete genome

Start: 18572, End: 18706, Length: 135

Host Lineage: Rickettsia rickettsii; Rickettsia; Rickettsiaceae; Rickettsiales; Proteobacteria; Bacteria

General Information: This genus, like other Rickettsial organisms such as Neorickettsia and Anaplasma, are obligate intracellular pathogens and is composed of two groups, the spotted fever group, and the typhus group. The latter is composed of two organisms, Rickettsia prowazekii and Rickettsia typhi. The bacteria are transmitted via an insect, usually a tick, to a host organism, in this case humans, where they target endothelial cells and sometimes macrophages. They attach via an adhesin, rickettsial outer membrane protein A, and are internalized where they persist as cytoplasmically free organisms. This organism was first identified by Dr. Howard Rickets as the causative agent of Rocky Mountain Spotted Fever, which was originally named for its geographic distribution at the time, it is now known to be widespread throughout the North American continent. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. This bacterium is an obligate intracellular pathogen that infects primarily the vascular endothelium, and occasionally smooth muscle tissue. It is passed to the human host from a tick bite, and the tick acts as both a natural reservoir and a vector for disease transmission. Once the organism is endocytosed by the host cell, it quickly escapes the phagozome, and replicates intracellularly, causing cell death and tissue damage. The disease is characterized by a spotted rash and has a high mortality rate if left untreated.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016914:13826:185721857219300729Rickettsia rickettsii str. Hino chromosome, complete genomeDNA translocation competence protein1e-1788.2
NC_003103:12114:156871568716421735Rickettsia conorii str. Malish 7, complete genomesimilarity to competence locus E protein 32e-1788.2
NC_010263:13826:185721857219309738Rickettsia rickettsii str. Iowa, complete genomeDNA translocation competence protein1e-1788.2
NC_016913:1134000:114955011495501150287738Rickettsia rickettsii str. Brazil chromosome, complete genomeDNA translocation competence protein1e-1788.2
NC_016915:13927:186741867419402729Rickettsia rickettsii str. Hlp#2 chromosome, complete genomeDNA translocation competence protein1e-1788.2
NC_009882:13826:185721857219300729Rickettsia rickettsii str. 'Sheila Smith', complete genomehypothetical protein1e-1788.2
NC_016909:16465:185741857419302729Rickettsia rickettsii str. Arizona chromosome, complete genomeDNA translocation competence protein1e-1788.2
NC_016911:13826:185711857119299729Rickettsia rickettsii str. Hauke chromosome, complete genomeDNA translocation competence protein1e-1788.2
NC_017044:15697:187601876019377618Rickettsia parkeri str. Portsmouth chromosome, complete genomeDNA translocation competence protein2e-1787.8
NC_017065:13188:188771887719605729Rickettsia slovaca str. D-CWPP chromosome, complete genomeDNA translocation competence protein4e-1786.7
NC_015866:14071:184951849518938444Rickettsia heilongjiangensis 054 chromosome, complete genomeComEC/Rec2-like protein4e-1786.7
NC_017043:735150:737980737980738744765Rickettsia montanensis str. OSU 85-930 chromosome, complete genomeComEC/Rec2-like protein2e-1581.3
NC_017042:77363:934669346694428963Rickettsia rhipicephali str. 3-7-female6-CWPP chromosome, completeComEC/Rec2-like protein3e-1580.5