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Query: NC_016822:1818897:1828388 Shigella sonnei 53G, complete genome

Start: 1828388, End: 1828522, Length: 135

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017328:1835108:184645018464501847439990Shigella flexneri 2002017 chromosome, complete genomehypothetical protein2e-0960.8
NC_008258:1784637:179323117932311794220990Shigella flexneri 5 str. 8401, complete genomeputative glycoportein2e-0960.8
NC_004337:1783645:179390717939071794896990Shigella flexneri 2a str. 301, complete genomeputative glycoprotein2e-0960.8
NC_004741:1823000:183085318308531831842990Shigella flexneri 2a str. 2457T, complete genomeputative glycoprotein2e-0960.8
NC_011353:1971145:1978202197820219794611260Escherichia coli O157:H7 str. EC4115 chromosome, complete genomeleucine-rich repeat protein2e-0857.8
NC_002655:2015000:2023612202361220248711260Escherichia coli O157:H7 EDL933, complete genomehypothetical protein2e-0857.8
NC_002695:2056545:2063602206360220648611260Escherichia coli O157:H7 str. Sakai, complete genomehypothetical protein2e-0857.8
NC_013008:1971662:1977178197717819784371260Escherichia coli O157:H7 str. TW14359 chromosome, complete genomenon-LEE-encoded type III effector2e-0857.8
NC_013941:1857724:1868066186806618693251260Escherichia coli O55:H7 str. CB9615 chromosome, complete genomehypothetical protein2e-0857.8
NC_011750:1809943:1819362181936218206181257Escherichia coli IAI39 chromosome, complete genomehypothetical protein3e-0857
NC_011751:1714131:1739999173999917412941296Escherichia coli UMN026 chromosome, complete genomehypothetical protein3e-0857
NC_010498:1700447:1708354170835417096101257Escherichia coli SMS-3-5, complete genomehypothetical protein3e-0753.9