Pre_GI: BLASTP Hits

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Query: NC_016822:1781644:1781644 Shigella sonnei 53G, complete genome

Start: 1781644, End: 1782573, Length: 930

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017168:3192817:321471832147183215692975Yersinia pestis A1122 chromosome, complete genomeDNA replication terminus site-binding protein1e-93343
NC_005126:2756984:277530327753032776229927Photorhabdus luminescens subsp. laumondii TTO1, complete genomeDNA replication terminus site-binding protein1e-87323
NC_007482:607365:632567632567633442876Pseudoalteromonas haloplanktis TAC125 chromosome II, completeDNA replication terminus site-binding protein3e-22105