Pre_GI: BLASTP Hits

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Query: NC_016822:1339058:1360400 Shigella sonnei 53G, complete genome

Start: 1360400, End: 1360690, Length: 291

Host Lineage: Shigella sonnei; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This organism is the leading cause of dysentery in industrialized countries. The disease is usually less severe than other types of Shigella, causing mild diarrhea and dehydration.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_007384:1355060:137755213775521377842291Shigella sonnei Ss046, complete genomehypothetical protein7e-34142
NC_008258:1873805:189495018949501895240291Shigella flexneri 5 str. 8401, complete genome4e-33139
NC_010159:1668795:168498716849871685307321Yersinia pestis Angola, complete genomehypothetical protein3e-1787.4
NC_010634:2004653:200612920061292006449321Yersinia pseudotuberculosis PB1/+, complete genomeYebG family protein3e-1787.4
NC_016514:1142607:117505811750581175375318Enterobacter cloacae EcWSU1 chromosome, complete genomeprotein YecA5e-1683.2
NC_011184:597496:618276618276618566291Vibrio fischeri MJ11 chromosome I, complete sequenceDNA damage-inducible gene in SOS regulon, dependent on cyclic AMP and H-NS6e-0959.7