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Query: NC_016768:2764000 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 2764000, End: 2786700, Length: 22701

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_008752:10259801025980106353637557Acidovorax avenae subsp. citrulli AAC00-1, complete genome7e-1073.8BLASTN svgBLASTP svg
NC_013205:2610956*2610956266117350218Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446,3e-0661.9BLASTN svgBLASTP svg
NC_013855:1268424*1268424129242324000Azospirillum sp. B510 plasmid pAB510a, complete sequence3e-0661.9BLASTN svgBLASTP svg
NC_021150:16273471627347165194824602Azotobacter vinelandii CA6, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_012560:16273341627334164585618523Azotobacter vinelandii DJ, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_015376:20100092010009204069430686Burkholderia gladioli BSR3 chromosome chromosome 2, complete3e-1591.7BLASTN svgBLASTP svg
NC_002935:1315019*1315019137072155703Corynebacterium diphtheriae NCTC 13129, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_009664:1569335*1569335161469045356Kineococcus radiotolerans SRS30216, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_015387:10029551002955103001227058Marinithermus hydrothermalis DSM 14884 chromosome, complete genome7e-0763.9BLASTN svgBLASTP svg
NC_010172:57304657304660029627251Methylobacterium extorquens PA1, complete genome3e-0971.9BLASTN svgBLASTP svg
NC_002945:16217651621765164826226498Mycobacterium bovis AF2122/97, complete genome012190BLASTN svgBLASTP svg
NC_015848:28591452859145288297223828Mycobacterium canettii CIPT 140010059, complete genome3e-1281.8BLASTN svgBLASTP svg
NC_015848:16475231647523167029122769Mycobacterium canettii CIPT 140010059, complete genome015680BLASTN svgBLASTP svg
NC_019950:28306822830682285444023759Mycobacterium canettii CIPT 140060008 complete genome3e-1281.8BLASTN svgBLASTP svg
NC_020133:14439341443934146609922166Mycobacterium liflandii 128FXT, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_020133:57106615710661573224421584Mycobacterium liflandii 128FXT, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_020133:90200090200092552523526Mycobacterium liflandii 128FXT, complete genome8e-1693.7BLASTN svgBLASTP svg
NC_020133:50205005020500504274122242Mycobacterium liflandii 128FXT, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_020133:24219652421965244809926135Mycobacterium liflandii 128FXT, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_020133:2886541*2886541291380027260Mycobacterium liflandii 128FXT, complete genome02190BLASTN svgBLASTP svg
NC_020133:2144752*2144752217059925848Mycobacterium liflandii 128FXT, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_010612:95778695778698186224077Mycobacterium marinum M, complete genome2e-28135BLASTN svgBLASTP svg
NC_010612:54030005403000542141218413Mycobacterium marinum M, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_010612:22157242215724224185126128Mycobacterium marinum M, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_010612:61131556113155613265419500Mycobacterium marinum M, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_009565:16297801629780165615326374Mycobacterium tuberculosis F11, complete genome015850BLASTN svgBLASTP svg
NC_009525:39335673933567395892925363Mycobacterium tuberculosis H37Ra, complete genome2e-1075.8BLASTN svgBLASTP svg
NC_018681:56279405627940567856250623Nocardia brasiliensis ATCC 700358 chromosome, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_018524:57484215748421577627827858Nocardiopsis alba ATCC BAA-2165 chromosome, complete genome7e-47196BLASTN svgBLASTP svg
NC_009439:49137674913767493609922333Pseudomonas mendocina ymp, complete genome1e-0869.9BLASTN svgBLASTP svg
NC_009439:44289044289048900846119Pseudomonas mendocina ymp, complete genome2e-0765.9BLASTN svgBLASTP svg
NC_012522:75960397596039763616240124Rhodococcus opacus B4, complete genome1e-119438BLASTN svgBLASTP svg
NC_013521:2193203*2193203221998826786Sanguibacter keddieii DSM 10542, complete genome8e-19103BLASTN svgBLASTP svg