Pre_GI: BLASTP Hits

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Query: NC_016768:830000:843211 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 843211, End: 843480, Length: 270

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012943:830000:843207843207843476270Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein2e-46184
NC_002755:831397:844150844150844419270Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein2e-46184
NC_009525:830513:843315843315843584270Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein2e-46184
NC_008769:860670:873816873816874061246Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein8e-42168
NC_002945:831029:844223844223844468246Mycobacterium bovis AF2122/97, complete genomehypothetical protein8e-42168
NC_012207:831030:844176844176844421246Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein8e-42168
NC_016804:831500:844095844095844340246Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein8e-42168
NC_017026:829444:842529842529842774246Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein8e-42168
NC_009525:830513:833082833082833609528Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein3e-41167
NC_008769:860670:863241863241863768528Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein3e-41167
NC_012207:831030:833601833601834128528Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein3e-41167
NC_002945:831029:833600833600834127528Mycobacterium bovis AF2122/97, complete genomehypothetical protein3e-41167
NC_016804:831500:833520833520834047528Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein3e-41167
NC_009565:833076:835564835564836172609Mycobacterium tuberculosis F11, complete genomehypothetical protein2e-41167
NC_012943:830000:832695832695833303609Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein2e-41167
NC_016768:830000:832699832699833307609Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein2e-41167
NC_009565:833076:845902845902846147246Mycobacterium tuberculosis F11, complete genomehypothetical protein2e-41167
NC_002755:831397:834130834130834492363Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein4e-41166
NC_017026:829444:832555832555832800246Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein8e-39158