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Query: NC_016768:830000:839455 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 839455, End: 842058, Length: 2604

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012943:830000:8394518394518420542604Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein1e-1172.8
NC_016804:831500:8402378402378429182682Mycobacterium bovis BCG str. Mexico chromosome, complete genomePE-PGRS family protein1e-1172.8
NC_002945:831029:8403178403178430462730Mycobacterium bovis AF2122/97, complete genomePE-PGRS family protein1e-1172.8
NC_008769:860670:8699588699588726392682Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomePE-PGRS family protein1e-1172.8
NC_012207:831030:8403188403188429992682Mycobacterium bovis BCG str. Tokyo 172, complete genomePE-PGRS family protein1e-1172.8
NC_009565:833076:8423208423208447252406Mycobacterium tuberculosis F11, complete genomePE-PGRS family protein1e-1172.8
NC_009525:830513:8397578397578421622406Mycobacterium tuberculosis H37Ra, complete genomePE-PGRS family protein1e-1172.8
NC_002755:831397:8406408406408429972358Mycobacterium tuberculosis CDC1551, complete genomePE_PGRS family protein6e-1170.1