Some Help

Query: NC_016768:830000:836158 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 836158, End: 836685, Length: 528

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

Search Results with any or all of these Fields

Host Accession, e.g. NC_0123..Host Description, e.g. Clostri...
Host Lineage, e.g. archae, Proteo, Firmi...
Host Information, e.g. soil, Thermo, Russia

SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:829444:835652835652836179528Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein1e-66251
NC_016804:831500:836898836898837425528Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein1e-66251
NC_012943:830000:836154836154836681528Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein1e-66251
NC_002755:831397:837343837343837870528Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein1e-66251
NC_009565:833076:839023839023839550528Mycobacterium tuberculosis F11, complete genomehypothetical protein1e-66251
NC_002945:831029:836978836978837505528Mycobacterium bovis AF2122/97, complete genomehypothetical protein1e-66251
NC_012207:831030:836979836979837506528Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein1e-66251
NC_008769:860670:866619866619867146528Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein1e-66251
NC_016948:419500:4369964369964393292334Mycobacterium intracellulare MOTT-64 chromosome, complete genomeATP-dependent rna helicase, dead/deah box family protein8e-1063.2