Pre_GI: BLASTP Hits

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Query: NC_016768:830000:835444 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 835444, End: 835950, Length: 507

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:829444:834937834937835443507Mycobacterium tuberculosis RGTB327 chromosome, complete genometranscriptional regulator2e-82304
NC_008769:860670:865905865905866411507Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative transcriptional regulatory protein2e-82304
NC_012207:831030:836265836265836771507Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transcriptional regulatory protein2e-82304
NC_009525:830513:835746835746836252507Mycobacterium tuberculosis H37Ra, complete genomeputative transcriptional regulatory protein2e-82304
NC_009565:833076:838309838309838815507Mycobacterium tuberculosis F11, complete genomehypothetical transcriptional regulatory protein2e-82304
NC_002945:831029:836264836264836770507Mycobacterium bovis AF2122/97, complete genometranscriptional regulatory protein2e-82304
NC_012943:830000:835440835440835946507Mycobacterium tuberculosis KZN 1435 chromosome, complete genometranscriptional regulator2e-82304
NC_016804:831500:836184836184836690507Mycobacterium bovis BCG str. Mexico chromosome, complete genometranscriptional regulator2e-82304
NC_002755:831397:836629836629837168540Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein3e-82303
NC_014830:3156873:317380531738053174317513Intrasporangium calvum DSM 43043 chromosome, complete genomeDNA binding domain protein, excisionase family7e-38156
NC_014151:856354:860494860494861030537Cellulomonas flavigena DSM 20109 chromosome, complete genomeDNA binding domain protein, excisionase family1e-23108