Pre_GI: BLASTP Hits

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Query: NC_016768:830000:831859 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 831859, End: 832665, Length: 807

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:829444:831352831352832158807Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein9e-124442
NC_012943:830000:831855831855832661807Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein9e-124442
NC_002755:831397:833045833045833851807Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein9e-124442
NC_009525:830513:832161832161832967807Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein9e-124442
NC_009565:833076:834727834727835530804Mycobacterium tuberculosis F11, complete genomehypothetical protein3e-123441
NC_016804:831500:832557832557833405849Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein2e-120432
NC_012207:831030:832638832638833486849Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein2e-120432
NC_002945:831029:832637832637833485849Mycobacterium bovis AF2122/97, complete genomehypothetical protein2e-120432
NC_008769:860670:862278862278863126849Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein2e-120432