Pre_GI: BLASTP Hits

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Query: NC_016768:2764000:2785049 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 2785049, End: 2785960, Length: 912

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015848:1647523:164752316475231648434912Mycobacterium canettii CIPT 140010059, complete genomeputative OXPP cycle protein OPCA2e-170598
NC_018524:5748421:575341957534195754339921Nocardiopsis alba ATCC BAA-2165 chromosome, complete genomeglucose-6-phosphate dehydrogenase subunit9e-61233
NC_002935:1315019:131669313166931317652960Corynebacterium diphtheriae NCTC 13129, complete genomehypothetical protein1e-58226
NC_016783:1313008:131468213146821315641960Corynebacterium diphtheriae INCA 402 chromosome, complete genomeoxppcycle protein OpcA1e-58226
NC_016787:1276983:127980112798011280760960Corynebacterium diphtheriae HC03 chromosome, complete genomeoxppcycle protein OpcA1e-58226
NC_016788:1286974:128979212897921290751960Corynebacterium diphtheriae HC04 chromosome, complete genomeoxppcycle protein OpcA1e-58226
NC_016789:1334514:133618813361881337147960Corynebacterium diphtheriae PW8 chromosome, complete genomeoxppcycle protein OpcA1e-58226
NC_016799:1343020:134583813458381346797960Corynebacterium diphtheriae 31A chromosome, complete genomeoxppcycle protein OpcA1e-58226
NC_016800:1317276:131895013189501319909960Corynebacterium diphtheriae BH8 chromosome, complete genomeoxppcycle protein OpcA1e-58226
NC_016801:1333860:133551313355131336472960Corynebacterium diphtheriae C7 (beta) chromosome, complete genomeoxppcycle protein OpcA1e-58226
NC_016802:1256287:129128212912821292241960Corynebacterium diphtheriae HC02 chromosome, complete genomeoxppcycle protein OpcA1e-58226
NC_016785:1270295:127196912719691272928960Corynebacterium diphtheriae CDCE 8392 chromosome, complete genomeoxppcycle protein OpcA1e-58226
NC_014643:2056280:209893220989322099918987Rothia dentocariosa ATCC 17931 chromosome, complete genomeoxppcycle protein OpcA2e-51202