Pre_GI: BLASTP Hits

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Query: NC_016768:2764000:2782334 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 2782334, End: 2783455, Length: 1122

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009565:1629780:1631321163132116324421122Mycobacterium tuberculosis F11, complete genometransaldolase0757
NC_002945:1621765:1623306162330616244271122Mycobacterium bovis AF2122/97, complete genometransaldolase0755
NC_015848:1647523:1650028165002816511491122Mycobacterium canettii CIPT 140010059, complete genomeputative transaldolase TAL0751
NC_020133:2886541:2886541288654128876621122Mycobacterium liflandii 128FXT, complete genometransaldolase Tal0645
NC_012522:7596039:7597587759758775987111125Rhodococcus opacus B4, complete genometransaldolase2e-161568
NC_016788:1286974:1286974128697412880561083Corynebacterium diphtheriae HC04 chromosome, complete genometransaldolase7e-121434
NC_016783:1274000:1311864131186413129461083Corynebacterium diphtheriae INCA 402 chromosome, complete genometransaldolase7e-121434
NC_016787:1276983:1276983127698312780651083Corynebacterium diphtheriae HC03 chromosome, complete genometransaldolase8e-121433
NC_016802:1256287:1288464128846412895461083Corynebacterium diphtheriae HC02 chromosome, complete genometransaldolase8e-121433
NC_016799:1343020:1343020134302013441021083Corynebacterium diphtheriae 31A chromosome, complete genometransaldolase1e-120432
NC_018524:5748421:5750609575060957517151107Nocardiopsis alba ATCC BAA-2165 chromosome, complete genometransaldolase5e-119427
NC_014643:2056280:2101680210168021027861107Rothia dentocariosa ATCC 17931 chromosome, complete genometransaldolase3e-117421
NC_007484:293763:2976832976832988131131Nitrosococcus oceani ATCC 19707, complete genometransaldolase7e-88324
NC_013960:1587761:1611133161113316140782946Nitrosococcus halophilus Nc4 chromosome, complete genometransaldolase1e-86320
NC_015757:963447:9793319793319821052775Sulfobacillus acidophilus TPY chromosome, complete genometransaldolase2e-78293
NC_016884:2568920:2568920256892025716942775Sulfobacillus acidophilus DSM 10332 chromosome, complete genometransaldolase, glucose-6-phosphate isomerase2e-78293
NC_005125:3570385:3587545358754535886661122Gloeobacter violaceus PCC 7421, complete genometransaldolase1e-78293
NC_007925:4060635:4082795408279540856472853Rhodopseudomonas palustris BisB18, complete genometransaldolase4e-76285
NC_015731:25493:3868438684397601077Nitrosomonas sp. Is79A3 chromosome, complete genometransaldolase6e-72271
NC_015942:787808:7973267973267984051080Acidithiobacillus ferrivorans SS3 chromosome, complete genometransaldolase1e-58227
NC_008699:1247423:1248186124818612493011116Nocardioides sp. JS614, complete genomeTransaldolase1e-1171.2
NC_006085:481231:4999214999215009971077Propionibacterium acnes KPA171202, complete genometransaldolase9e-1168.2
NC_014039:499233:5179185179185189941077Propionibacterium acnes SK137 chromosome, complete genometransaldolase1e-1067.8
NC_016511:472666:4913554913554924311077Propionibacterium acnes TypeIA2 P.acn31 chromosome, completetransaldolase1e-1067.8
NC_016516:463460:4821514821514832271077Propionibacterium acnes TypeIA2 P.acn33 chromosome, completetransaldolase1e-1067.8
NC_015408:1035690:105617710561771057160984Chlamydophila pecorum E58 chromosome, complete genometransaldolase5e-0962.4
NC_015761:2444833:244738424473842448334951Salmonella bongori NCTC 12419, complete genometransaldolase A5e-0859.3
NC_006841:750000:757439757439758389951Vibrio fischeri ES114 chromosome II, complete sequencetransaldolase7e-0858.5
NC_011186:819828:830370830370831320951Vibrio fischeri MJ11 chromosome II, complete sequencetransaldolase7e-0858.5
NC_015687:1478668:149181414918141492461648Clostridium acetobutylicum DSM 1731 chromosome, complete genomeputative translaldolase2e-0757.4
NC_017243:3093393:309541330954133096066654Brachyspira intermedia PWS/A chromosome, complete genometransaldolase4e-0756.2
NC_008262:784878:805105805105805752648Clostridium perfringens SM101, complete genometransaldolase, putative4e-0756.2
NC_017328:2586171:260429926042992605249951Shigella flexneri 2002017 chromosome, complete genomeTransaldolase5e-0755.8
NC_004741:2526421:254479425447942545744951Shigella flexneri 2a str. 2457T, complete genometransaldolase5e-0755.8
NC_008258:2542863:256247525624752563425951Shigella flexneri 5 str. 8401, complete genometransaldolase A5e-0755.8
NC_012225:2247796:226551122655112266164654Brachyspira hyodysenteriae WA1, complete genometransaldolase6e-0755.5
NC_012488:349862:373201373201373857657Listeria monocytogenes Clip81459, complete genomeputative translaldolase1e-0654.7
NC_004337:2548288:256666125666612567611951Shigella flexneri 2a str. 301, complete genometransaldolase2e-0653.9
NC_011969:726369:737213737213737860648Bacillus cereus Q1 chromosome, complete genometranslaldolase2e-0653.9
NC_016771:701909:715573715573716220648Bacillus cereus NC7401, complete genometransaldolase2e-0653.9
NC_014532:3479674:348413434841343485081948Halomonas elongata DSM 2581, complete genometransaldolase2e-0653.9
NC_019970:2551607:257046225704622571109648Thermoanaerobacterium thermosaccharolyticum M0795, complete genomefructose-6-phosphate aldolase, TalC/MipB family3e-0653.5
NC_006274:659922:676248676248676895648Bacillus cereus E33L, complete genometransaldolase3e-0653.1
NC_003997:674265:687916687916688563648Bacillus anthracis str. Ames, complete genometransaldolase3e-0653.1
NC_005945:674337:687812687812688459648Bacillus anthracis str. Sterne, complete genometransaldolase3e-0653.1
NC_005957:667954:678799678799679446648Bacillus thuringiensis serovar konkukian str. 97-27, completetransaldolase3e-0653.1
NC_007530:674265:687917687917688564648Bacillus anthracis str. 'Ames Ancestor', complete genometransaldolase3e-0653.1
NC_011725:681387:691786691786692433648Bacillus cereus B4264 chromosome, complete genometranslaldolase3e-0653.1
NC_011773:688689:702354702354703001648Bacillus cereus AH820 chromosome, complete genomeputative translaldolase3e-0653.1
NC_012659:678289:687817687817688464648Bacillus anthracis str. A0248, complete genomeputative translaldolase3e-0653.1
NC_016779:657568:669327669327669974648Bacillus cereus F837/76 chromosome, complete genomeTransaldolase3e-0653.1
NC_010468:3970995:399311039931103994063954Escherichia coli ATCC 8739, complete genometransaldolase5e-0652.8
CP002516:4081484:410143341014334102386954Escherichia coli KO11, complete genometransaldolase5e-0652.8
NC_012947:3753375:377453337745333775486954Escherichia coli 'BL21-Gold(DE3)pLysS AG' chromosome, completetransaldolase B5e-0652.8
NC_016902:4081484:410143341014334102386954Escherichia coli KO11FL chromosome, complete genometransaldolase5e-0652.8
NC_015555:2259500:229877022987702299417648Thermoanaerobacterium xylanolyticum LX-11 chromosome, completetransaldolase4e-0652.8
NC_019814:320260:326623326623327576954Candidatus Kinetoplastibacterium blastocrithidii (ex Strigomonastransaldolase4e-0652.8
NC_004722:650950:661348661348661995648Bacillus cereus ATCC 14579, complete genometransaldolase4e-0652.8
NC_008752:1025980:102768710276871028634948Acidovorax avenae subsp. citrulli AAC00-1, complete genometransaldolase5e-0652.4
NC_008027:3953951:396983739698373970763927Pseudomonas entomophila L48, complete genometransaldolase6e-0652
NC_016612:2223357:222584222258422226795954Klebsiella oxytoca KCTC 1686 chromosome, complete genometransaldolase B8e-0652
NC_013851:2610847:263174726317472632718972Allochromatium vinosum DSM 180 chromosome, complete genometransaldolase1e-0551.6