Pre_GI: BLASTP Hits

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Query: NC_016768:2764000:2770546 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 2770546, End: 2771844, Length: 1299

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009565:1629780:1642932164293216442301299Mycobacterium tuberculosis F11, complete genomehypothetical transcriptional activator protein0872
NC_002945:1621765:1635127163512716363921266Mycobacterium bovis AF2122/97, complete genometranscriptional activator protein0848
NC_015848:1647523:1662481166248116637461266Mycobacterium canettii CIPT 140010059, complete genomeputative transcriptional activator protein0847
NC_011770:3396637:3396637339663733978361200Pseudomonas aeruginosa LESB58, complete genomehypothetical protein7e-69261
NC_014414:167803:1678031678031690141212Parvularcula bermudensis HTCC2503 chromosome, complete genomehypothetical protein8e-54211
NC_008268:3233961:3255809325580932570531245Rhodococcus sp. RHA1, complete genomehypothetical protein2e-25117
NC_013929:1611940:1632189163218916334301242Streptomyces scabiei 87.22 chromosome, complete genomehypothetical protein1e-22107
NC_018681:7624000:7640808764080876418781071Nocardia brasiliensis ATCC 700358 chromosome, complete genomeFis family transcriptional regulator2e-1790.5
NC_013159:2832552:2835826283582628371511326Saccharomonospora viridis DSM 43017, complete genomeregulator of polyketide synthase expression5e-1789.4
NC_009338:4913510:4919772491977249210641293Mycobacterium gilvum PYR-GCK chromosome, complete genomehypothetical protein9e-1065.1
NC_021184:3912805:3930546393054639328402295Desulfotomaculum gibsoniae DSM 7213, complete genomehypothetical protein1e-0655.1
NC_011184:2421687:2421687242168724228321146Vibrio fischeri MJ11 chromosome I, complete sequencecarbohydrate diacid regulator3e-0653.5