Pre_GI: BLASTP Hits

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Query: NC_016768:2764000:2767767 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 2767767, End: 2768699, Length: 933

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016802:1256287:128387312838731284811939Corynebacterium diphtheriae HC02 chromosome, complete genomecytochrome aa3 controlling protein3e-37155
NC_016782:1251796:128297212829721283910939Corynebacterium diphtheriae 241 chromosome, complete genomecytochrome aa3 controlling protein3e-37155
NC_016783:1274000:130727213072721308210939Corynebacterium diphtheriae INCA 402 chromosome, complete genomecytochrome aa3 controlling protein3e-37155
NC_016786:1251765:128294112829411283879939Corynebacterium diphtheriae HC01 chromosome, complete genomecytochrome aa3 controlling protein3e-37155
NC_016788:1214026:128238212823821283320939Corynebacterium diphtheriae HC04 chromosome, complete genomecytochrome aa3 controlling protein3e-37155
NC_016799:1268706:133842813384281339366939Corynebacterium diphtheriae 31A chromosome, complete genomecytochrome aa3 controlling protein3e-37155
NC_016790:1218596:124977012497701250708939Corynebacterium diphtheriae VA01 chromosome, complete genomecytochrome aa3 controlling protein3e-37155
NC_016800:1243000:131154013115401312478939Corynebacterium diphtheriae BH8 chromosome, complete genomecytochrome aa3 controlling protein3e-37155
NC_009664:3718927:372174037217403722636897Kineococcus radiotolerans SRS30216, complete genomecytochrome oxidase assembly5e-1168.6
NC_009565:1629780:164607716460771647009933Mycobacterium tuberculosis F11, complete genomehypothetical antibiotic-transport integral membrane ABC transporter4e-98357
NC_012522:7596039:760349276034927604454963Rhodococcus opacus B4, complete genomehypothetical membrane protein2e-61236
NC_002935:1237585:130928313092831310221939Corynebacterium diphtheriae NCTC 13129, complete genomehypothetical protein3e-37155
NC_014643:2056280:2106577210657721076231047Rothia dentocariosa ATCC 17931 chromosome, complete genomehypothetical protein2e-0859.7
NC_015848:1647523:166559316655931666525933Mycobacterium canettii CIPT 140010059, complete genomeputative unidentified antibiotic-transport integral membrane ABC transporter1e-97356
NC_002945:1621765:163823916382391639171933Mycobacterium bovis AF2122/97, complete genomeunidentified antibiotic-transport integral membrane ABC transporter4e-98357