Pre_GI: BLASTP Hits

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Query: NC_016768:2101751:2123583 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 2123583, End: 2125118, Length: 1536

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012943:2103662:2125494212549421270291536Mycobacterium tuberculosis KZN 1435 chromosome, complete genomecarboxylesterase lipT0982
NC_009338:4869700:4888704488870448902121509Mycobacterium gilvum PYR-GCK chromosome, complete genometype B carboxylesterase5e-179627
NC_014329:844622:8501598501598517781620Corynebacterium pseudotuberculosis FRC41 chromosome, completehypothetical protein5e-71268
NC_016781:844613:8501508501508517691620Corynebacterium pseudotuberculosis 3/99-5 chromosome, completecarboxylesterase, LipT6e-71268
NC_016932:832748:8382858382858399041620Corynebacterium pseudotuberculosis 316 chromosome, complete genomeCarboxylesterase, LipT6e-71268
NC_020272:599064:6162346162346176821449Bacillus amyloliquefaciens IT-45, complete genomecarboxylesterase type B1e-69264
NC_016582:9050528:9054058905405890555481491Streptomyces bingchenggensis BCW-1 chromosome, complete genomecarboxylesterase7e-58225
NC_014158:1566310:1575507157550715770961590Tsukamurella paurometabola DSM 20162 chromosome, complete genomeCarboxylesterase1e-55217
NC_009511:1781914:1800636180063618021411506Sphingomonas wittichii RW1 chromosome, complete genometype B carboxylesterase1e-54214
NC_016593:3116145:3136791313679131382901500Geobacillus thermoleovorans CCB_US3_UF5 chromosome, completethermostable carboxylesterase Est501e-54214
NC_016943:2054688:2073374207337420748641491Blastococcus saxobsidens DD2, complete genomecarboxylesterase6e-54212
NC_014624:2668157:2685725268572526873081584Eubacterium limosum KIST612 chromosome, complete genomeCarboxylesterase1e-53211
NC_010067:1300606:1318421131842113199291509Salmonella enterica subsp. arizonae serovar 62:z4,z23:--, completehypothetical protein7e-53208
NC_007164:380000:3942153942153958641650Corynebacterium jeikeium K411, complete genomeputative type B carboxylesterase2e-52207
NC_015727:1076927:1091019109101910925571539Cupriavidus necator N-1 plasmid BB1p, complete sequencepara-nitrobenzyl esterase PnbA2e-52207
NC_011149:1429523:1493933149393314954411509Salmonella enterica subsp. enterica serovar Agona str. SL483,carboxylesterase, type B5e-52206
NC_010102:1388344:1410355141035514118631509Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,hypothetical protein3e-52206
NC_011205:1633353:1655396165539616569041509Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853carboxylesterase, type B3e-52206
NC_012125:2143246:2165270216527021667781509Salmonella enterica subsp. enterica serovar Paratyphi C strainesterase9e-52204
NC_011294:1493849:1515875151587515173831509Salmonella enterica subsp. enterica serovar Enteritidis stresterase2e-51203
NC_011274:1544653:1566681156668115681891509Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91esterase6e-51202
NC_003198:1378457:1392475139247513939831509Salmonella enterica subsp. enterica serovar Typhi str. CT18,putative esterase3e-51202
NC_004631:1587000:1587198158719815887061509Salmonella enterica subsp. enterica serovar Typhi Ty2, completeputative esterase3e-51202
NC_016832:1582273:1584148158414815856561509Salmonella enterica subsp. enterica serovar Typhi str. P-stx-12,Carboxylesterase, type B3e-51202
NC_018681:7624000:7636364763636476378091446Nocardia brasiliensis ATCC 700358 chromosome, complete genomepara-nitrobenzyl esterase2e-50201
NC_015957:7533000:7537807753780775391891383Streptomyces violaceusniger Tu 4113 chromosome, complete genomecarboxylesterase type B4e-50199
NC_008278:613329:6153256153256171301806Frankia alni ACN14a, complete genomePutative carboxylesterase4e-50199
NC_010676:2975572:2976990297699029786991710Burkholderia phytofirmans PsJN chromosome 2, complete sequenceCarboxylesterase type B9e-50198
NC_013205:526281:5283655283655298371473Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446,Carboxylesterase1e-49197
NC_015690:4469775:4529261452926145307451485Paenibacillus mucilaginosus KNP414 chromosome, complete genomePnbA3e-49196
NC_016935:4233223:4285097428509742865811485Paenibacillus mucilaginosus 3016 chromosome, complete genomeprotein PnbA5e-49195
NC_012214:2019000:2020448202044820219741527Erwinia pyrifoliae Ep1/96, complete genomePutative carboxylesterase1e-48194
NC_009077:4671417:4672238467223846736441407Mycobacterium sp. JLS, complete genomeCarboxylesterase, type B9e-47188
NC_013192:1504310:1512473151247315141431671Leptotrichia buccalis DSM 1135, complete genomeCarboxylesterase type B9e-46185
NC_019968:382991:4407564407564423031548Prevotella dentalis DSM 3688 chromosome 2, complete sequencecarboxylesterase type B5e-44179
NC_016023:1839503:1858703185870318601751473Bacillus coagulans 36D1 chromosome, complete genomecarboxylesterase type B6e-44179
NC_008542:197500:2011752011752028721698Burkholderia cenocepacia HI2424 chromosome 1, complete sequenceCarboxylesterase, type B9e-44178
NC_009142:2725000:2748343274834327498331491Saccharopolyspora erythraea NRRL 2338, complete genomeputative para-nitrobenzyl esterase5e-43176
NC_013510:262888:2813672813672830101644Thermomonospora curvata DSM 43183, complete genomeCarboxylesterase1e-42174
NC_019968:382991:4423564423564439601605Prevotella dentalis DSM 3688 chromosome 2, complete sequencecarboxylesterase type B3e-42173
NC_013595:235931:2366442366442381971554Streptosporangium roseum DSM 43021, complete genomeAcetylcholinesterase4e-40166
NC_012669:2399649:2400330240033024019641635Beutenbergia cavernae DSM 12333, complete genomeCarboxylesterase type B6e-40165
NC_013222:3060482:3078887307888730804071521Robiginitalea biformata HTCC2501, complete genomeputative esterase6e-39162
NC_014169:1909482:1913689191368919151311443Bifidobacterium longum subsp. longum JDM301 chromosome, completeputative esterase3e-37157
NC_014041:3715000:3744734374473437463951662Zunongwangia profunda SM-A87 chromosome, complete genomecarboxylesterase type B3e-36153
NC_013730:4811911:4825402482540248270571656Spirosoma linguale DSM 74, complete genomeCarboxylesterase type B1e-35151
NC_012791:651480:6685616685616698531293Variovorax paradoxus S110 chromosome 1, complete genomeCarboxylesterase type B2e-33144
NC_016111:6175975:6180455618045561817021248Streptomyces cattleya NRRL 8057, complete genomeTMC biosynthetic enzyme L12e-30134
NC_020291:4502467:4515812451581245175811770Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomecarboxylesterase type B3e-30133
NC_016582:10287865:1030572810305728103070591332Streptomyces bingchenggensis BCW-1 chromosome, complete genomeputative carboxyesterase1e-28128
NC_003295:2787371:2798145279814527995721428Ralstonia solanacearum GMI1000, complete genomePUTATIVE CARBOXYLESTERASE PROTEIN3e-27123
NC_016887:5607272:5626796562679656280791284Nocardia cyriacigeorgica GUH-2, complete genomeputative carboxyesterase6e-25115
NC_015277:5211779:5213081521308152144181338Sphingobacterium sp. 21 chromosome, complete genomeCarboxylesterase type B3e-23110
NC_009480:739395:7499847499847513691386Clavibacter michiganensis subsp. michiganensis NCPPB 382, completeputative carboxylesterase, type B3e-20100
NC_002967:552000:5668465668465683421497Treponema denticola ATCC 35405, complete genomecarboxylesterase family protein6e-1995.9
NC_016790:1702856:1707379170737917085781200Corynebacterium diphtheriae VA01 chromosome, complete genomeputative type B carboxylesterase3e-1377.4
NC_002935:1763886:1770335177033517715341200Corynebacterium diphtheriae NCTC 13129, complete genomePutative drug resistance protein (hydrolase)3e-1377.4
NC_016801:1782401:1786924178692417881231200Corynebacterium diphtheriae C7 (beta) chromosome, complete genomeputative type B carboxylesterase3e-1377
NC_016789:1805503:1810026181002618112251200Corynebacterium diphtheriae PW8 chromosome, complete genomeputative type B carboxylesterase3e-1377
NC_016783:1758319:1762842176284217640411200Corynebacterium diphtheriae INCA 402 chromosome, complete genomeputative type B carboxylesterase3e-1377
NC_016802:1709840:1719593171959317207921200Corynebacterium diphtheriae HC02 chromosome, complete genomeputative type B carboxylesterase3e-1377
NC_016782:1745374:1755127175512717563261200Corynebacterium diphtheriae 241 chromosome, complete genomeputative type B carboxylesterase3e-1377
NC_016786:1751204:1755727175572717569261200Corynebacterium diphtheriae HC01 chromosome, complete genomeputative type B carboxylesterase3e-1377
NC_016787:1726978:1731501173150117327001200Corynebacterium diphtheriae HC03 chromosome, complete genomeputative type B carboxylesterase3e-1377
NC_016788:1730458:1734981173498117361801200Corynebacterium diphtheriae HC04 chromosome, complete genomeputative type B carboxylesterase3e-1377
NC_016799:1787687:1795017179501717962161200Corynebacterium diphtheriae 31A chromosome, complete genomeputative type B carboxylesterase3e-1377
NC_011898:2509267:252684325268432527778936Clostridium cellulolyticum H10, complete genomeAlpha/beta hydrolase fold-3 domain protein1e-1171.6
NC_010995:4460413:4481283448128344822901008Cellvibrio japonicus Ueda107, complete genomelipase2e-1171.2
NC_003888:8569962:857436485743648575071708Streptomyces coelicolor A3(2), complete genomehydrolase2e-0964.7
NC_012912:1200000:121396212139621214930969Dickeya zeae Ech1591, complete genomeAlpha/beta hydrolase fold-3 domain protein1e-0964.7
NC_014727:1136589:115751711575171158371855Lactobacillus delbrueckii subsp. bulgaricus ND02 chromosome,hydrolase, alpha/beta domain protein3e-0963.5
NC_008010:222516:242562242562243506945Deinococcus geothermalis DSM 11300 plasmid 1, complete sequencelipase, active site4e-0963.5
NC_001263:132288:132288132288133178891Deinococcus radiodurans R1 chromosome 1, complete sequencelipase/esterase, putative1e-0861.6
NC_016845:2781438:278820627882062789162957Klebsiella pneumoniae subsp. pneumoniae HS11286 chromosome,esterase/lipase2e-0757.8
NC_012731:2739964:274783927478392748822984Klebsiella pneumoniae NTUH-K2044 chromosome, complete genomeesterase/lipase3e-0757.4
NC_009664:4347718:4351256435125643525361281Kineococcus radiotolerans SRS30216, complete genomeAlpha/beta hydrolase fold-3 domain protein2e-0757.4
NC_009848:2335265:233935023393502340219870Bacillus pumilus SAFR-032, complete genomepeptidase9e-0755.5
NC_012669:4323490:4340163434016343412181056Beutenbergia cavernae DSM 12333, complete genomeAlpha/beta hydrolase fold-3 domain protein1e-0655.1
NC_016885:2294000:231701223170122317956945Pyrobaculum oguniense TE7 chromosome, complete genomeesterase/lipase1e-0655.1
NC_014623:2475598:2483165248316524842141050Stigmatella aurantiaca DW4/3-1 chromosome, complete genomealpha/beta fold family hydrolase3e-0653.9
NC_016048:797762:815010815010815960951Oscillibacter valericigenes Sjm18-20, complete genomeputative hydrolase3e-0653.9
NC_012726:255774:259671259671260588918Sulfolobus islandicus M.16.4 chromosome, complete genomeAlpha/beta hydrolase fold-3 domain-containing protein4e-0653.1
NC_012632:243982:247879247879248796918Sulfolobus islandicus M.16.27 chromosome, complete genomeAlpha/beta hydrolase fold-3 domain-containing protein4e-0653.1
NC_008268:7180663:719891971989197199851933Rhodococcus sp. RHA1, complete genomepossible esterase6e-0652.8
NC_012623:2555000:255580125558012556718918Sulfolobus islandicus Y.N.15.51 chromosome, complete genomeAlpha/beta hydrolase fold-3 domain-containing protein6e-0652.8
NC_012589:260703:262019262019262936918Sulfolobus islandicus L.S.2.15, complete genomeAlpha/beta hydrolase fold-3 domain protein6e-0652.8
NC_013158:1620761:1628800162880016298011002Halorhabdus utahensis DSM 12940, complete genomeEsterase/lipase-like protein7e-0652.8