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Query: NC_016768:2101751:2107145 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 2107145, End: 2107507, Length: 363

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012943:2103662:210905621090562109418363Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein2e-34144
NC_009565:2306574:232190523219052322267363Mycobacterium tuberculosis F11, complete genomehypothetical protein2e-34144
NC_017026:2286000:230061023006102300834225Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein1e-1582
NC_016804:2254979:227031022703102270534225Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein1e-1582
NC_013159:2098500:210298521029852103419435Saccharomonospora viridis DSM 43017, complete genomehypothetical protein4e-1063.5
NC_017186:5184000:519315951931595193539381Amycolatopsis mediterranei S699 chromosome, complete genomehypothetical protein5e-0959.7
NC_014318:5183975:519312551931255193505381Amycolatopsis mediterranei U32 chromosome, complete genomehypothetical protein5e-0959.7
NC_019673:4687289:470631747063174706700384Saccharothrix espanaensis DSM 44229 complete genomehypothetical protein3e-0857.4
NC_009142:2480608:248299824829982483348351Saccharopolyspora erythraea NRRL 2338, complete genomehypothetical protein4e-0856.6