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Query: NC_016768:2101751:2106644 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 2106644, End: 2106979, Length: 336

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:2286000:230113823011382301473336Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein1e-44178
NC_016804:2254979:227083822708382271173336Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein1e-44178
NC_012943:2103662:210855521085552108890336Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein1e-44178
NC_009565:2306574:232243323224332322768336Mycobacterium tuberculosis F11, complete genomehypothetical protein1e-44178
NC_002677:1716000:173334717333471733682336Mycobacterium leprae TN, complete genomehypothetical protein4e-43173
NC_011896:1716000:173328017332801733615336Mycobacterium leprae Br4923, complete genomehypothetical protein4e-43173
NC_007164:1090858:111079611107961111173378Corynebacterium jeikeium K411, complete genomehypothetical protein2e-32137
NC_016783:1216708:122485512248551225244390Corynebacterium diphtheriae INCA 402 chromosome, complete genomehypothetical protein5e-31132
NC_016785:1167057:117903411790341179423390Corynebacterium diphtheriae CDCE 8392 chromosome, complete genomehypothetical protein5e-31132
NC_016789:1232993:124295812429581243347390Corynebacterium diphtheriae PW8 chromosome, complete genomehypothetical protein5e-31132
NC_016790:1152249:116578711657871166176390Corynebacterium diphtheriae VA01 chromosome, complete genomehypothetical protein5e-31132
NC_016800:1219121:122738612273861227775390Corynebacterium diphtheriae BH8 chromosome, complete genomehypothetical protein5e-31132
NC_016802:1186326:119830511983051198694390Corynebacterium diphtheriae HC02 chromosome, complete genomehypothetical protein5e-31132
NC_017186:5184000:519771851977185198065348Amycolatopsis mediterranei S699 chromosome, complete genomehypothetical protein2e-29127
NC_014318:5183975:519768451976845198031348Amycolatopsis mediterranei U32 chromosome, complete genomehypothetical protein2e-29127
NC_009921:4948500:496522449652244965868645Frankia sp. EAN1pec, complete genomehypothetical protein1e-25115
NC_007777:2638580:264748826474882647838351Frankia sp. CcI3, complete genomehypothetical protein4e-25113
NC_009953:2727669:274749127474912747832342Salinispora arenicola CNS-205 chromosome, complete genomehypothetical protein7e-25112
NC_009380:2548878:256755025675502567891342Salinispora tropica CNB-440 chromosome, complete genomehypothetical protein1e-24112
NC_015434:3507059:352746135274613527802342Verrucosispora maris AB-18-032 chromosome, complete genomehypothetical protein1e-24111
NC_014165:2081914:208582920858292086173345Thermobispora bispora DSM 43833 chromosome, complete genomehypothetical protein5e-2199.8
NC_008278:4023918:404582640458264046137312Frankia alni ACN14a, complete genomeconserved hypothetical protein; putative copper ion binding domain2e-1890.9