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Query: NC_016768:1279178:1286413 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 1286413, End: 1287540, Length: 1128

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015873:1487127:1499561149956115007421182Megasphaera elsdenii DSM 20460, complete genomeCRISPR-associated RAMP protein5e-1479
NC_002945:3073370:3082802308280230839291128Mycobacterium bovis AF2122/97, complete genomehypothetical protein0778
NC_016804:3049631:3059582305958230607091128Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein0778
NC_008769:3070266:3080217308021730813441128Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein0778
NC_012207:3063039:3072990307299030741171128Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein0778
NC_015848:3175692:3186227318622731873541128Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein1e-165582
NC_019950:3139865:3150610315061031517371128Mycobacterium canettii CIPT 140060008 complete genomeConserved CRISPR-associated protein of unknown function Csm51e-165582
NC_002755:3110929:3120445312044531215721128Mycobacterium tuberculosis CDC1551, complete genomeCRISPR-associated TM1807 family protein0778
NC_009565:3128094:3137869313786931389961128Mycobacterium tuberculosis F11, complete genomehypothetical protein0778
NC_009525:3128786:3138231313823131393581128Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein0778
NC_000962:3116818:3126240312624031273671128Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein0778
NC_012943:1279228:1286469128646912875961128Mycobacterium tuberculosis KZN 1435 chromosome, complete genomecsm5 family CRISPR-associated ramp protein0778
NC_017026:3110155:3120083312008331212101128Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein0778
NC_014377:532816:5380055380055391261122Thermosediminibacter oceani DSM 16646 chromosome, complete genomeCRISPR-associated RAMP protein, Csm5 family4e-0859.7