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Query: NC_016768:1279178:1279178 Mycobacterium tuberculosis KZN 4207 chromosome, complete genome

Start: 1279178, End: 1280062, Length: 885

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:3110155:312755231275523128436885Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein9e-167585
NC_009565:3128094:314534731453473146237891Mycobacterium tuberculosis F11, complete genomehypothetical protein9e-167585
NC_012943:1279228:127922812792281280118891Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein9e-167585
NC_008769:3070266:308769530876953088579885Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein9e-167585
NC_002945:3073370:309028030902803091164885Mycobacterium bovis AF2122/97, complete genomehypothetical protein9e-167585
NC_012207:3063039:308046830804683081352885Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein9e-167585
NC_000962:3116818:313370931337093134593885Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein9e-167585
NC_009525:3128786:314570131457013146585885Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein9e-167585
NC_016804:3049631:306706030670603067944885Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein9e-167585
NC_002755:3110929:312792331279233128813891Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein9e-167585