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Query: NC_016516:2380131:2398377 Propionibacterium acnes TypeIA2 P.acn33 chromosome, complete

Start: 2398377, End: 2398724, Length: 348

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016512:2388612:240685724068572407204348Propionibacterium acnes TypeIA2 P.acn17 chromosome, completehypothetical protein1e-61234
NC_016511:2389273:240751924075192407866348Propionibacterium acnes TypeIA2 P.acn31 chromosome, completehypothetical protein1e-61234
NC_014039:2386347:240459324045932404940348Propionibacterium acnes SK137 chromosome, complete genomehypothetical protein1e-61234
NC_011899:2286884:229225322922532292564312Halothermothrix orenii H 168, complete genomehypothetical protein2e-2097.8
NC_010003:1242846:125195012519501252252303Petrotoga mobilis SJ95, complete genomehypothetical protein1e-1891.7
NC_010718:1229355:123598912359891236309321Natranaerobius thermophilus JW/NM-WN-LF, complete genomehypothetical protein2e-1787.8
NC_009718:1771500:179261517926151792950336Fervidobacterium nodosum Rt17-B1, complete genomehypothetical protein4e-1683.2
NC_016751:1604048:161132216113221611627306Marinitoga piezophila KA3 chromosome, complete genomehypothetical protein3e-1580.5