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Query: NC_016516:2380131:2396022 Propionibacterium acnes TypeIA2 P.acn33 chromosome, complete

Start: 2396022, End: 2396537, Length: 516

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016511:2389273:2405163240516324061701008Propionibacterium acnes TypeIA2 P.acn31 chromosome, completeAsnC family transcriptional regulator1e-96351
NC_016512:2388612:240450224045022405017516Propionibacterium acnes TypeIA2 P.acn17 chromosome, completeAsnC family transcriptional regulator1e-96351
NC_014039:2386347:2402237240223724032441008Propionibacterium acnes SK137 chromosome, complete genometranscriptional regulator, AsnC family2e-95347
NC_008596:4043213:4059480405948040604811002Mycobacterium smegmatis str. MC2 155, complete genometranscriptional regulator, AsnC family protein8e-1786.3
NC_006361:2225072:2227312222731222283611050Nocardia farcinica IFM 10152, complete genomehypothetical protein2e-1375.5
NC_018750:6717315:6735355673535567364101056Streptomyces venezuelae ATCC 10712, complete genomeTranscriptional regulator, AsnC family2e-1375.1
NC_018531:2085939:2102825210282521038321008Arthrobacter sp. Rue61a chromosome, complete genomehypothetical protein6e-0753.5
NC_015957:4963500:4973688497368849747131026Streptomyces violaceusniger Tu 4113 chromosome, complete genomeAsnC family transcriptional regulator7e-0753.1