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Query: NC_016512:305240:306070 Propionibacterium acnes TypeIA2 P.acn17 chromosome, complete

Start: 306070, End: 306555, Length: 486

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_021064:2001786:200282320028232003308486Propionibacterium avidum 44067, complete genomehypothetical protein1e-85315
NC_013595:480000:502178502178502663486Streptosporangium roseum DSM 43021, complete genomeputative phosphohistidine phosphatase, SixA7e-1269.7
NC_013132:782846:797595797595798095501Chitinophaga pinensis DSM 2588, complete genomeputative phosphohistidine phosphatase, SixA9e-1062.8
NC_016582:9664000:968050796805079681025519Streptomyces bingchenggensis BCW-1 chromosome, complete genomehypothetical protein8e-0959.7
NC_004307:579729:582281582281582838558Bifidobacterium longum NCC2705, complete genomenarrowly conserved hypothetical protein8e-0959.3
NC_015052:1094825:111776311177631118320558Bifidobacterium longum subsp. infantis 157F, complete genomephosphoglycerate3e-0857.8
NC_015067:998500:101674310167431017300558Bifidobacterium longum subsp. longum JCM 1217, complete genomephosphoglycerate3e-0857.8
NC_013715:193647:209287209287209832546Rothia mucilaginosa DY-18, complete genomephosphohistidine phosphatase SixA1e-0755.5
NC_014616:1065500:108098610809861081543558Bifidobacterium bifidum S17 chromosome, complete genomephosphohistidine phosphatase, SixA2e-0755.5
NC_012803:361127:365549365549366073525Micrococcus luteus NCTC 2665, complete genomephosphohistidine phosphatase SixA5e-0753.5
NC_014638:1043854:106981110698111070368558Bifidobacterium bifidum PRL2010 chromosome, complete genomephosphohistidine phosphatase5e-0753.5
NC_010338:426388:425879425879426391513Caulobacter sp. K31, complete genomeputative phosphohistidine phosphatase, SixA4e-0650.8