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Query: NC_016511:1811171:1818002 Propionibacterium acnes TypeIA2 P.acn31 chromosome, complete

Start: 1818002, End: 1818862, Length: 861

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016516:1799521:180891218089121809772861Propionibacterium acnes TypeIA2 P.acn33 chromosome, completehypothetical protein4e-148523
NC_016512:1810625:181745618174561818316861Propionibacterium acnes TypeIA2 P.acn17 chromosome, completehypothetical protein4e-148523
NC_014039:1813205:182007218200721820932861Propionibacterium acnes SK137 chromosome, complete genomehypothetical protein5e-148523
NC_011740:3739395:374777837477783748230453Escherichia fergusonii ATCC 35469, complete genomeconserved hypothetical protein; putative permease6e-23108
NC_011740:3739395:374693037469303747805876Escherichia fergusonii ATCC 35469, complete genomehypothetical protein1e-1067.4
NC_013316:891782:8962838962838976381356Clostridium difficile R20291, complete genomehypothetical protein7e-1064.7
NC_013315:895500:8986688986689000231356Clostridium difficile CD196 chromosome, complete genomehypothetical protein7e-1064.7
NC_009089:965959:9691499691499704111263Clostridium difficile 630, complete genomehypothetical protein7e-1064.7
NC_017179:905347:9085389085389098001263Clostridium difficile BI1, complete genomehypothetical protein7e-1064.7
NC_009922:868262:8889488889488902041257Alkaliphilus oremlandii OhILAs, complete genomeDicarboxylate carrier MatC domain protein3e-0859.3
NC_015859:3346473:3347327334732733486551329Corynebacterium variabile DSM 44702 chromosome, complete genomehypothetical protein8e-0651.2