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Query: NC_016511:1354949:1376504 Propionibacterium acnes TypeIA2 P.acn31 chromosome, complete

Start: 1376504, End: 1377493, Length: 990

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016516:1345840:136739413673941368383990Propionibacterium acnes TypeIA2 P.acn33 chromosome, completecysteine synthase/ornithine cyclodeaminase0635
NC_006085:1379370:140090614009061401895990Propionibacterium acnes KPA171202, complete genomecysteine synthase/ornithine cyclodeaminase0635
NC_016512:1357225:137594913759491376938990Propionibacterium acnes TypeIA2 P.acn17 chromosome, completecysteine synthase/ornithine cyclodeaminase2e-179628
NC_008786:1332041:1341562134156213425871026Verminephrobacter eiseniae EF01-2, complete genomeornithine cyclodeaminase/mu-crystallin3e-67255
NC_012914:5938566:595818659581865959154969Paenibacillus sp. JDR-2, complete genomeornithine cyclodeaminase/mu-crystallin1e-23110
NC_009464:1397739:140147014014701402441972Uncultured methanogenic archaeon RC-I, complete genomeornithine cyclodeaminase9e-1581.3
NC_015320:790137:8061088061088071151008Archaeoglobus veneficus SNP6 chromosome, complete genomealanine dehydrogenase2e-1170.1
NC_014011:1264165:127453912745391275531993Aminobacterium colombiense DSM 12261 chromosome, complete genomeOrnithine cyclodeaminase3e-1169.7
NC_014507:2568933:258515825851582586093936Methanoplanus petrolearius DSM 11571 chromosome, complete genomeornithine cyclodeaminase5e-0962
NC_013202:906044:935148935148936140993Halomicrobium mukohataei DSM 12286, complete genomeOrnithine cyclodeaminase2e-0756.6