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Query: NC_016511:1212282:1219898 Propionibacterium acnes TypeIA2 P.acn31 chromosome, complete

Start: 1219898, End: 1220908, Length: 1011

Host Lineage: Propionibacterium acnes; Propionibacterium; Propionibacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This bacterium is the most common gram-positive, non-spore forming, anaerobic rod encountered in clinical specimens. The causative agent of acne, it typically grows as an obligate anaerobe. Some strains are aerotolerant, but still show better growth as an anaerobe. It has the ability to produce propionic acid, as its name suggests. It also has the ability to produce catalase along with indole, nitrate, or both indole and nitrate. Propionibacterium resembles Corynebacterium in morphology and arrangement, but is non-toxigenic. It is a common resident of the pilosebaceous (hair follicle) glands of the human skin. The bacteria release lipases to digest a surplus of the skin oil, sebum, that has been produced. The combination of digestive products (fatty acids) and bacterial antigens stimulates an intense local inflammation that bursts the hair follicle. Since acne is caused in part from an infection, it can be suppressed with topical and oral antibiotics such as clindamycin, erythromycin, or tetracycline. Some other forms of therapy include chemicals that enhance skin removal or slow the production of sebum.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016516:1203000:1210715121071512117251011Propionibacterium acnes TypeIA2 P.acn33 chromosome, completeTat (twin-arginine translocation) pathway signal sequence0636
NC_016512:1211653:1219269121926912202791011Propionibacterium acnes TypeIA2 P.acn17 chromosome, completeTat (twin-arginine translocation) pathway signal sequence0636
NC_014039:1238500:1246251124625112472551005Propionibacterium acnes SK137 chromosome, complete genomeTat (twin-arginine translocation) pathway signal sequence0633
NC_006085:1234587:1244212124421212452161005Propionibacterium acnes KPA171202, complete genomehypothetical protein6e-171600