Pre_GI: BLASTP Hits

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Query: NC_015848:3343731:3359724 Mycobacterium canettii CIPT 140010059, complete genome

Start: 3359724, End: 3360869, Length: 1146

Host Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_019950:3306419:3324033332403333251781146Mycobacterium canettii CIPT 140060008 complete genomePutative oxidoreductase0743
NC_009565:3299937:3314576331457633157211146Mycobacterium tuberculosis F11, complete genomehypothetical oxidoreductase0741
NC_009525:3300456:3315095331509533162401146Mycobacterium tuberculosis H37Ra, complete genomeN5,N10-methylenetetrahydromethanopterin reductase-related protein0741
NC_008769:3242453:3257264325726432584091146Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative oxidoreductase0741
NC_012207:3237440:3250091325009132512361146Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative oxidoreductase0741
NC_002945:3246278:3259791325979132609361146Mycobacterium bovis AF2122/97, complete genomeoxidoreductase0741
NC_000962:3288464:3303103330310333042481146Mycobacterium tuberculosis H37Rv, complete genomePOSSIBLE OXIDOREDUCTASE0741
NC_016804:3221818:3236629323662932377741146Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative oxidoreductase0741
NC_017026:3282405:3297048329704832981931146Mycobacterium tuberculosis RGTB327 chromosome, complete genomeoxidoreductase0741
NC_002755:3282785:3297424329742432985691146Mycobacterium tuberculosis CDC1551, complete genomeN5,N10-methylenetetrahydromethanopterin reductase-related protein0741
NC_002677:173170:1754411754411765891149Mycobacterium leprae TN, complete genomeputative oxidoreductase0648
NC_011896:173197:1754681754681766161149Mycobacterium leprae Br4923, complete genomeputative oxidoreductase0648
NC_014830:3438504:3463866346386634650021137Intrasporangium calvum DSM 43043 chromosome, complete genomeLuciferase-like, subgroup2e-45183
NC_013849:19404:4081540815418311017Ferroglobus placidus DSM 10642 chromosome, complete genomeLuciferase-like, subgroup2e-22107
NC_013849:627811:645634645634646632999Ferroglobus placidus DSM 10642 chromosome, complete genome5,10-methylenetetrahydromethanopterin reductase3e-22106
NC_015562:1299648:130121013012101302205996Methanotorris igneus Kol 5 chromosome, complete genome5,10-methylenetetrahydromethanopterin reductase4e-22105
NC_016948:1761020:1781064178106417822091146Mycobacterium intracellulare MOTT-64 chromosome, complete genomeluciferase family protein2e-21103
NC_014122:143446:148423148423149418996Methanocaldococcus infernus ME chromosome, complete genome5,10-methylenetetrahydromethanopterin reductase2e-20100
NC_016948:1761020:1786148178614817872871140Mycobacterium intracellulare MOTT-64 chromosome, complete genomeluciferase family protein2e-20100
NC_017904:1831071:1854041185404118551771137Mycobacterium sp. MOTT36Y chromosome, complete genomeluciferase family protein1e-1997.4
NC_014253:2113233:213386221338622134848987Methanohalobium evestigatum Z-7303 chromosome, complete genome5,10-methylenetetrahydromethanopterin reductase2e-1894
NC_013407:146000:162714162714163709996Methanocaldococcus vulcanius M7, complete genome5,10-methylenetetrahydromethanopterin reductase1e-1790.9
NC_015574:1970967:198397119839711984936966Methanobacterium sp. SWAN-1 chromosome, complete genome5,10-methylenetetrahydromethanopterin reductase8e-1788.2
NC_003551:478065:4872644872644883131050Methanopyrus kandleri AV19, complete genomemethylenetetrahydromethanopterin reductase2e-1377
NC_009515:510121:522158522158523123966Methanobrevibacter smithii ATCC 35061, complete genomemethylenetetrahydromethanopterin reductase6e-1375.5
NC_013790:756000:758519758519759475957Methanobrevibacter ruminantium M1 chromosome, complete genome5,10-methylenetetrahydromethanopterin reductase Mer9e-1375.1
NC_008278:925231:939757939757940668912Frankia alni ACN14a, complete genomehypothetical protein6e-1065.5
NC_014165:2888961:2906558290655829081891632Thermobispora bispora DSM 43833 chromosome, complete genomeluciferase-like monooxygenase2e-0963.9
NC_008271:140846:159267159267160157891Rhodococcus sp. RHA1 plasmid pRHL3, complete sequencepossible hybride transferase/ F420-dependent dehydrogenase2e-0963.5
NC_017186:7480714:750030975003097501199891Amycolatopsis mediterranei S699 chromosome, complete genomeflavin-dependent oxidoreductase3e-0963.2
NC_014318:7480669:750026475002647501154891Amycolatopsis mediterranei U32 chromosome, complete genomeputative flavin-dependent oxidoreductase3e-0963.2
NC_012669:96966:116343116343117266924Beutenbergia cavernae DSM 12333, complete genomeLuciferase-like monooxygenase4e-0962.8
NC_013131:8480384:852485585248558525784930Catenulispora acidiphila DSM 44928, complete genomeLuciferase-like monooxygenase9e-0961.6
NC_016906:1458158:147728314772831478281999Gordonia polyisoprenivorans VH2 chromosome, complete genomeputative F420-dependent oxidoreductase2e-0860.8
NC_008268:2313583:2314567231456723155741008Rhodococcus sp. RHA1, complete genomeprobable 5,10-methylenetetrahydromethanopterin reductase1e-0860.8
NC_008271:35909:5945859458604651008Rhodococcus sp. RHA1 plasmid pRHL3, complete sequencepossible F420-dependent glucose-6-phosphate dehydrogenase2e-0860.5
NC_013131:2517861:253478725347872535719933Catenulispora acidiphila DSM 44928, complete genomehypothetical protein2e-0860.5
NC_012522:2031786:2033292203329220342991008Rhodococcus opacus B4, complete genomeF420-dependent glucose-6-phosphate dehydrogenase3e-0859.7
NC_021177:7815791:783722278372227838139918Streptomyces fulvissimus DSM 40593, complete genomeHydride transferase 18e-0858.5
NC_008271:140846:1615081615081625211014Rhodococcus sp. RHA1 plasmid pRHL3, complete sequenceprobable glucose-6-phosphate 1-dehydrogenase7e-0858.5
NC_013523:2560000:2577966257796625790451080Sphaerobacter thermophilus DSM 20745 chromosome 1, complete genomeLuciferase-like monooxygenase2e-0757
NC_013510:3117837:3148924314892431499521029Thermomonospora curvata DSM 43183, complete genomeLuciferase-like monooxygenase3e-0756.6
NC_014507:2196539:219954921995492200547999Methanoplanus petrolearius DSM 11571 chromosome, complete genome5,10-methylenetetrahydromethanopterin reductase4e-0756.2
NC_010612:835648:8529698529698539791011Mycobacterium marinum M, complete genomeF420-dependent glucose-6-phosphate dehydrogenase Fgd14e-0755.8
NC_011896:332939:3530233530233540331011Mycobacterium leprae Br4923, complete genomeputative F420-dependent glucose-6-phosphate dehydrogenase6e-0755.5
NC_002677:332923:3530073530073540171011Mycobacterium leprae TN, complete genomeputative F420-dependent glucose-6-phosphate dehydrogenase6e-0755.5
NC_015957:5136500:513912751391275140086960Streptomyces violaceusniger Tu 4113 chromosome, complete genomeluciferase-like protein1e-0654.3
NC_009921:565947:570804570804571682879Frankia sp. EAN1pec, complete genomeluciferase family protein2e-0653.9
NC_000962:475816:4907834907834917931011Mycobacterium tuberculosis H37Rv, complete genomePROBABLE F420-DEPENDENT GLUCOSE-6-PHOSPHATE DEHYDROGENASE FGD13e-0653.5
NC_012207:477500:4919314919314929411011Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative F420-dependent glucose-6-phosphate dehydrogenase3e-0653.5
NC_008769:507000:5215985215985226081011Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative f420-dependent glucose-6-phosphate dehydrogenase fgd13e-0653.5
NC_002755:472872:4922324922324932421011Mycobacterium tuberculosis CDC1551, complete genomeglucose-6-phosphate dehydrogenase, F420-dependent3e-0653.5
NC_009565:479500:4939534939534949631011Mycobacterium tuberculosis F11, complete genomeF420-dependent glucose-6-phosphate dehydrogenase fgd13e-0653.5
NC_009525:477093:4920934920934931031011Mycobacterium tuberculosis H37Ra, complete genomeputative f420-dependent glucose-6-phosphate dehydrogenase Fgd13e-0653.5
NC_002945:476835:4918024918024928121011Mycobacterium bovis AF2122/97, complete genomeF420-dependent glucose-6-phosphate dehydrogenase3e-0653.5
NC_012943:476500:4910424910424920521011Mycobacterium tuberculosis KZN 1435 chromosome, complete genomeF420-dependent glucose-6-phosphate dehydrogenase3e-0653.5
NC_016768:476500:4910424910424920521011Mycobacterium tuberculosis KZN 4207 chromosome, complete genomeF420-dependent glucose-6-phosphate dehydrogenase fgd13e-0653.5
NC_016804:477500:4919324919324929421011Mycobacterium bovis BCG str. Mexico chromosome, complete genomeF420-dependent glucose-6-phosphate dehydrogenase3e-0653.5
NC_009921:5508000:551469555146955515615921Frankia sp. EAN1pec, complete genomeluciferase family protein2e-0653.5
NC_011831:2795819:279855027985502799305756Chloroflexus aggregans DSM 9485, complete genomesugar transporter superfamily protein2e-0653.5
NC_016604:1285277:1306137130613713071471011Mycobacterium rhodesiae NBB3 chromosome, complete genomeglucose-6-phosphate dehydrogenase (coenzyme-F420)3e-0653.1
NC_015848:483500:5011525011525021621011Mycobacterium canettii CIPT 140010059, complete genomeputative F420-dependent glucose-6-phosphate dehydrogenase FGD13e-0653.1
NC_018750:6717315:6722665672266567236781014Streptomyces venezuelae ATCC 10712, complete genomeF420-dependent N(5),N(10)-methylenetetrahydromethanopterin reductase4e-0652.8
NC_013159:2098500:2135470213547021365251056Saccharomonospora viridis DSM 43017, complete genomeflavin-dependent oxidoreductase, F420-dependent methylene-tetrahydromethanopterin reductase4e-0652.8
NC_019950:481881:4971714971714981811011Mycobacterium canettii CIPT 140060008 complete genomeF420-dependent glucose-6-phosphate dehydrogenase Fgd17e-0652
NC_012669:96966:1135891135891146291041Beutenbergia cavernae DSM 12333, complete genomeLuciferase-like monooxygenase7e-0652
NC_013530:423540:4431224431224453832262Xylanimonas cellulosilytica DSM 15894, complete genomeFAD linked oxidase domain protein8e-0651.6