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Query: NC_015848:3343731:3356592 Mycobacterium canettii CIPT 140010059, complete genome

Start: 3356592, End: 3357191, Length: 600

Host Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:3282405:329391632939163294515600Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein2e-113407
NC_002755:3282785:329429232942923294930639Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein3e-113407
NC_002945:3246278:325665932566593257258600Mycobacterium bovis AF2122/97, complete genomehypothetical protein2e-113407
NC_009525:3300456:331196333119633312562600Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein2e-113407
NC_009565:3299937:331144433114443312043600Mycobacterium tuberculosis F11, complete genomehypothetical protein2e-113407
NC_019950:3306419:332090133209013321500600Mycobacterium canettii CIPT 140060008 complete genomeChorismate pyruvate lyase2e-113407
NC_012207:3237440:324695932469593247558600Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein2e-113407
NC_008769:3242453:325413232541323254731600Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein2e-113407
NC_000962:3288464:329997132999713300570600Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein2e-113407
NC_016804:3221818:323349732334973234096600Mycobacterium bovis BCG str. Mexico chromosome, complete genomechorismate--pyruvate lyase2e-113407
NC_002677:173170:179256179256179888633Mycobacterium leprae TN, complete genomehypothetical protein4e-66250
NC_011896:173197:179283179283179915633Mycobacterium leprae Br4923, complete genomehypothetical protein4e-66250
NC_010612:103081:114798114798115397600Mycobacterium marinum M, complete genome4-hydroxybenzoate synthetase (chorismate lyase)2e-42171
NC_020133:77341:814098140982128720Mycobacterium liflandii 128FXT, complete genome4-hydroxybenzoate synthetase1e-41169
NC_007796:1291671:1291671129167112932301560Methanospirillum hungatei JF-1, complete genomeGHMP kinase group 11e-0963.2