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Query: NC_015848:3343731:3347067 Mycobacterium canettii CIPT 140010059, complete genome

Start: 3347067, End: 3347768, Length: 702

Host Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:3282405:328456532845653285266702Mycobacterium tuberculosis RGTB327 chromosome, complete genomeputative lipoprotein LPPX9e-121432
NC_002755:3282785:328494532849453285646702Mycobacterium tuberculosis CDC1551, complete genomelipoprotein, putative9e-121432
NC_008769:3242453:324461332446133245314702Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative lipoprotein lppX9e-121432
NC_009525:3300456:330261633026163303317702Mycobacterium tuberculosis H37Ra, complete genomeputative conserved lipoprotein LppX9e-121432
NC_000962:3288464:329062432906243291325702Mycobacterium tuberculosis H37Rv, complete genomePROBABLE CONSERVED LIPOPROTEIN LPPX9e-121432
NC_019950:3306419:331149033114903312191702Mycobacterium canettii CIPT 140060008 complete genomeConserved lipoprotein of unknown function, LppX9e-121432
NC_002945:3246278:324719732471973247898702Mycobacterium bovis AF2122/97, complete genomelipoprotein LppX9e-121432
NC_012207:3237440:323744032374403238141702Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative lipoprotein9e-121432
NC_009565:3299937:330209733020973302798702Mycobacterium tuberculosis F11, complete genomelipoprotein lppX9e-121432
NC_016804:3221818:322397832239783224679702Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative lipoprotein9e-121432
NC_002677:173170:188551188551189252702Mycobacterium leprae TN, complete genomeputative lipoprotein3e-88324
NC_011896:173197:188578188578189279702Mycobacterium leprae Br4923, complete genomeputative lipoprotein3e-88324
NC_014168:1294000:132461113246111325342732Segniliparus rotundus DSM 44985 chromosome, complete genomehypothetical protein3e-43174
NC_006361:5146000:515248451524845153290807Nocardia farcinica IFM 10152, complete genomeputative lipoprotein2e-0756.2