Pre_GI: BLASTP Hits

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Query: NC_015848:3343731:3343731 Mycobacterium canettii CIPT 140010059, complete genome

Start: 3343731, End: 3346493, Length: 2763

Host Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_019950:3306419:3308199330819933109162718Mycobacterium canettii CIPT 140060008 complete genomePutative membrane transport protein MmpL701435
NC_011896:173197:1892801892801919882709Mycobacterium leprae Br4923, complete genomehypothetical protein0928
NC_002677:173170:1892531892531919612709Mycobacterium leprae TN, complete genomehypothetical protein0928
NC_010612:90890:9532995329981932865Mycobacterium marinum M, complete genomeconserved transmembrane transport protein, MmpL5_35e-35150
NC_002944:1881405:1899239189923919021392901Mycobacterium avium subsp. paratuberculosis K-10, complete genomeMmpL57e-34146
NC_010397:4150596:4178667417866741815462880Mycobacterium abscessus chromosome Chromosome, complete sequencePutative membrane protein, MmpL1e-33145
NC_012207:2573562:2584562258456225870422481Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transmembrane transport protein1e-32142
NC_016804:2560000:2571155257115525736352481Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative transmembrane transport protein1e-32142
NC_008596:421882:4257604257604286422883Mycobacterium smegmatis str. MC2 155, complete genomeMmp14a protein2e-30135
NC_016948:3381848:3396653339665333995682916Mycobacterium intracellulare MOTT-64 chromosome, complete genomemmpL4_22e-29131
NC_017904:3415700:3430505343050534334202916Mycobacterium sp. MOTT36Y chromosome, complete genomemmpL4_23e-29131
NC_002944:1285436:1301816130181613047342919Mycobacterium avium subsp. paratuberculosis K-10, complete genomeMmpL4_27e-27123
NC_010612:3969244:3979902397990239828112910Mycobacterium marinum M, complete genomeconserved transmembrane transport protein - MmpL family2e-1895.5
NC_016947:3309898:332471033247103325273564Mycobacterium intracellulare MOTT-02 chromosome, complete genomemmpL4_23e-1894.7
NC_017904:2641270:2641270264127026441732904Mycobacterium sp. MOTT36Y chromosome, complete genomemmpL57e-1893.6
NC_010397:4150596:4175704417570441786672964Mycobacterium abscessus chromosome Chromosome, complete sequencePutative membrane protein, MmpL7e-1790.1
NC_010397:4387500:4387612438761243905152904Mycobacterium abscessus chromosome Chromosome, complete sequencePutative membrane protein, MmpL family5e-1687
NC_010612:835648:8391118391118419872877Mycobacterium marinum M, complete genomeconserved transmembrane transport protein MmpL16e-1687
NC_016947:70210:8074780747836322886Mycobacterium intracellulare MOTT-02 chromosome, complete genomeMmpL family protein2e-1585.1
NC_002945:476835:4824744824744842491776Mycobacterium bovis AF2122/97, complete genometransmembrane transport protein MmpL1A5e-1584
NC_012207:477500:4826034826034843781776Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transmembrane transport protein5e-1584
NC_015848:483500:4876444876444905202877Mycobacterium canettii CIPT 140010059, complete genomeputative transmembrane transport protein MMPL15e-1584
NC_019950:481881:4866934866934895692877Mycobacterium canettii CIPT 140060008 complete genomePutative transmembrane transport protein MmpL15e-1584
NC_017026:476500:4813984813984835362139Mycobacterium tuberculosis RGTB327 chromosome, complete genometransporter5e-1584
NC_008596:421882:4286524286524316362985Mycobacterium smegmatis str. MC2 155, complete genomeputative transport protein5e-1584
NC_008769:507000:5122705122705140451776Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative transmembrane transport protein mmpL1a5e-1584
NC_016804:477500:4826044826044843791776Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative transmembrane transport protein5e-1584
NC_009525:477093:4816654816654845412877Mycobacterium tuberculosis H37Ra, complete genometransmembrane transport protein MmpL15e-1584
NC_009565:479500:4835254835254864012877Mycobacterium tuberculosis F11, complete genometransmembrane transport protein mmpL15e-1584
NC_000962:475816:4803554803554832312877Mycobacterium tuberculosis H37Rv, complete genomePROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL15e-1584
NC_002755:472872:4804464804464833222877Mycobacterium tuberculosis CDC1551, complete genomemembrane protein, MmpL family5e-1584
NC_012943:476500:4806144806144834902877Mycobacterium tuberculosis KZN 1435 chromosome, complete genometransmembrane transporter mmpL15e-1584
NC_016768:476500:4806144806144834902877Mycobacterium tuberculosis KZN 4207 chromosome, complete genometransmembrane transporter mmpL15e-1584
NC_017904:2379387:2419426241942624223232898Mycobacterium sp. MOTT36Y chromosome, complete genomeMmpL4 protein2e-1482.4
NC_016948:1796989:1809658180965818124682811Mycobacterium intracellulare MOTT-64 chromosome, complete genomemmpL4_62e-1482
NC_017904:3415700:3427590342759034304152826Mycobacterium sp. MOTT36Y chromosome, complete genomemmp14A protein5e-1480.9
NC_002944:1285436:1304793130479313076842892Mycobacterium avium subsp. paratuberculosis K-10, complete genomeMmpL4_39e-1479.7
NC_016947:3309898:3321728332172833246852958Mycobacterium intracellulare MOTT-02 chromosome, complete genomemmp14A protein1e-1379.7
NC_002944:4163490:4186438418643841893772940Mycobacterium avium subsp. paratuberculosis K-10, complete genomeMmpL4_52e-1379
NC_016948:3381848:3393669339366933965632895Mycobacterium intracellulare MOTT-64 chromosome, complete genomemmp14A protein2e-1378.6
NC_014168:1294000:1310581131058113134392859Segniliparus rotundus DSM 44985 chromosome, complete genometransport protein4e-1377.8
NC_014168:2575799:2583216258321625860532838Segniliparus rotundus DSM 44985 chromosome, complete genomeMMPL domain-containing protein6e-1377
NC_010612:3969244:3976045397604539789542910Mycobacterium marinum M, complete genomeconserved transmembrane transport protein - MmpL family1e-1275.9
NC_008699:2294361:2313454231345423164953042Nocardioides sp. JS614, complete genomeMMPL domain protein1e-1069.7
NC_002945:1680751:1698302169830217016253324Mycobacterium bovis AF2122/97, complete genometransmembrane transport protein MmpL122e-1068.9
NC_016804:1679357:1696909169690917002323324Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative transmembrane transport protein2e-1068.9
NC_012207:1681971:1699523169952317028463324Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transmembrane transport protein2e-1068.9
NC_008769:1709078:1726630172663017299533324Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative transmembrane transport protein mmpL122e-1068.9
NC_008705:5144433:5163375516337551664433069Mycobacterium sp. KMS, complete genomeMMPL domain protein1e-0965.9
NC_008146:5106775:5124292512429251273603069Mycobacterium sp. MCS, complete genomeMMPL1e-0965.9
NC_017904:666285:6780176780176809622946Mycobacterium sp. MOTT36Y chromosome, complete genomeMmpL family transport protein8e-0860.1
NC_002677:1462233:1462233146223314651842952Mycobacterium leprae TN, complete genomeconserved large membrane protein3e-0758.2
NC_011896:1462258:1462258146225814652092952Mycobacterium leprae Br4923, complete genomehypothetical protein3e-0758.2
NC_016947:666627:6801266801266831222997Mycobacterium intracellulare MOTT-02 chromosome, complete genomeMmpL family transport protein8e-0756.6
NC_009338:4913510:4930736493073649327812046Mycobacterium gilvum PYR-GCK chromosome, complete genomeMMPL domain-containing protein1e-0656.2
NC_009077:4810379:4818713481871348218353123Mycobacterium sp. JLS, complete genomeMMPL domain protein2e-0655.5
NC_014814:1397429:1417525141752514206473123Mycobacterium sp. Spyr1 chromosome, complete genomeRND superfamily drug exporter1e-0553.1