Pre_GI: BLASTP Hits

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Query: NC_015848:1105892:1125549 Mycobacterium canettii CIPT 140010059, complete genome

Start: 1125549, End: 1126550, Length: 1002

Host Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:1095753:1115437111543711164381002Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein6e-180630
NC_016804:1095846:1115516111551611165171002Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein6e-180630
NC_002945:1095337:1115199111519911162001002Mycobacterium bovis AF2122/97, complete genomehypothetical protein6e-180630
NC_000962:1095078:1114748111474811157491002Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein6e-180630
NC_009525:1096386:1116056111605611170571002Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein6e-180630
NC_012207:1097228:1116898111689811178991002Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein6e-180630
NC_008769:1125567:1145237114523711462381002Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein6e-180630
NC_009565:1098847:1118516111851611195171002Mycobacterium tuberculosis F11, complete genomehypothetical protein6e-180630
NC_002755:1095105:111483711148371115787951Mycobacterium tuberculosis CDC1551, complete genomecyclic nucleotide-binding protein1e-170598
NC_009380:1663545:1664806166480616674122607Salinispora tropica CNB-440 chromosome, complete genomeN-acetyltransferase GCN56e-1892
NC_010172:57500:582055820558726522Methylobacterium extorquens PA1, complete genomeGCN5-related N-acetyltransferase5e-1582.4
NC_011894:2359128:237323323732332373769537Methylobacterium nodulans ORS 2060, complete genomeGCN5-related N-acetyltransferase3e-1376.3
NC_015572:65597:861608616086798639Methylomonas methanica MC09 chromosome, complete genomeGCN5-like N-acetyltransferase2e-1273.9
NC_003296:87313:903229032290921600Ralstonia solanacearum GMI1000 plasmid pGMI1000MP, completehypothetical protein2e-0757
NC_015566:4205854:4206592420659242092402649Serratia sp. AS12 chromosome, complete genomeGCN5-like N-acetyltransferase6e-0755.5
NC_013595:5333000:5333032533303253356832652Streptosporangium roseum DSM 43021, complete genomeAcyl-CoA synthetase (NDP forming)-like protein1e-0654.3
NC_020211:4168189:4168927416892741715752649Serratia marcescens WW4, complete genomeinhibiting acetyltransferase for acetyl-CoA synthetase2e-0653.9
NC_007963:1190847:1234921123492112376022682Chromohalobacter salexigens DSM 3043, complete genomeGCN5-related N-acetyltransferase2e-0653.5
NC_008314:1825223:183783418378341838370537Ralstonia eutropha H16 chromosome 2, complete sequencehypothetical protein4e-0652.4