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Query: NC_015848:1105892:1123191 Mycobacterium canettii CIPT 140010059, complete genome

Start: 1123191, End: 1124261, Length: 1071

Host Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016804:1095846:1113152111315211142281077Mycobacterium bovis BCG str. Mexico chromosome, complete genomeputative transmembrane protein1e-129463
NC_012207:1097228:1114534111453411156101077Mycobacterium bovis BCG str. Tokyo 172, complete genomeputative transmembrane protein1e-129463
NC_008769:1125567:1142873114287311439491077Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomeputative transmembrane protein1e-129463
NC_002945:1095337:1112835111283511139111077Mycobacterium bovis AF2122/97, complete genometransmembrane protein5e-129461
NC_009565:1098847:1116053111605311172281176Mycobacterium tuberculosis F11, complete genomeconserved transmembrane protein5e-129461
NC_002755:1095105:1112324111232411134991176Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein5e-129461
NC_009525:1096386:1113692111369211147681077Mycobacterium tuberculosis H37Ra, complete genomeputative conserved transmembrane protein3e-129461
NC_000962:1095078:1112384111238411134601077Mycobacterium tuberculosis H37Rv, complete genomePROBABLE CONSERVED TRANSMEMBRANE PROTEIN3e-129461
NC_017026:1095753:1113073111307311141491077Mycobacterium tuberculosis RGTB327 chromosome, complete genometransmembrane protein3e-129461
NC_010397:1099312:1101614110161411026271014Mycobacterium abscessus chromosome Chromosome, complete sequencehypothetical protein7e-33141
NC_006361:5146000:5167960516796051692701311Nocardia farcinica IFM 10152, complete genomehypothetical protein4e-1375.9
NC_014168:471000:483862483862484824963Segniliparus rotundus DSM 44985 chromosome, complete genomehypothetical protein1e-0758.2
NC_017186:9120711:914870191487019149540840Amycolatopsis mediterranei S699 chromosome, complete genomehypothetical protein9e-0651.6