Pre_GI: BLASTP Hits

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Query: NC_015848:1105892:1119385 Mycobacterium canettii CIPT 140010059, complete genome

Start: 1119385, End: 1119978, Length: 594

Host Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002945:1095337:110902911090291109622594Mycobacterium bovis AF2122/97, complete genomehypothetical protein1e-78291
NC_008769:1125567:113906711390671139660594Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein5e-78290
NC_012207:1097228:111072811107281111321594Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein5e-78290
NC_016804:1095846:110934611093461109939594Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein5e-78290
NC_000962:1095078:110857811085781109171594Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein4e-78290
NC_009565:1098847:111234611123461112939594Mycobacterium tuberculosis F11, complete genomehypothetical protein4e-78290
NC_009525:1096386:110988611098861110479594Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein4e-78290
NC_016768:3296478:329953032995303300123594Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein4e-78290
NC_017026:1095753:110926511092651109858594Mycobacterium tuberculosis RGTB327 chromosome, complete genome5-formyltetrahydrofolate cyclo-ligase4e-78290
NC_012943:3299744:330271833027183303389672Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein3e-78290
NC_002755:1095105:110861711086171109204588Mycobacterium tuberculosis CDC1551, complete genome5-formyltetrahydrofolate cyclo-ligase-related protein2e-77288
NC_017186:9120711:915257691525769153166591Amycolatopsis mediterranei S699 chromosome, complete genome5-formyltetrahydrofolate cyclo-ligase9e-26116
NC_006361:5146000:517259151725915173193603Nocardia farcinica IFM 10152, complete genomehypothetical protein4e-25114
NC_014168:471000:488006488006488560555Segniliparus rotundus DSM 44985 chromosome, complete genome5-formyltetrahydrofolate cyclo-ligase8e-1477
NC_012669:1011473:101147310114731012099627Beutenbergia cavernae DSM 12333, complete genome5-formyltetrahydrofolate cyclo-ligase7e-1373.6
NC_021064:1789980:181008418100841810704621Propionibacterium avidum 44067, complete genome5-formyltetrahydrofolate cyclo-ligase8e-1270.1
NC_014246:536338:558892558892559539648Mobiluncus curtisii ATCC 43063 chromosome, complete genome5-formyltetrahydrofolate cyclo-ligase5e-1167.8
NC_014221:266638:270898270898271458561Truepera radiovictrix DSM 17093 chromosome, complete genome5-formyltetrahydrofolate cyclo-ligase2e-0755.8
NC_015160:2521849:252184925218492522382534Odoribacter splanchnicus DSM 20712 chromosome, complete genome5-formyltetrahydrofolate cyclo-ligase1e-0653.1
NC_013174:2163947:216394721639472164591645Jonesia denitrificans DSM 20603, complete genome5-formyltetrahydrofolate cyclo-ligase1e-0652.8
NC_013421:553193:578901578901579542642Pectobacterium wasabiae WPP163, complete genome5-formyltetrahydrofolate cyclo-ligase4e-0651.6
NC_010162:9727465:973004997300499730654606Sorangium cellulosum 'So ce 56', complete genomeputative 5-formyltetrahydrofolate cyclo-ligase5e-0650.8
NC_002946:1935186:195353919535391954198660Neisseria gonorrhoeae FA 1090, complete genomehypothetical protein9e-0650.1