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Query: NC_015848:1105892:1118979 Mycobacterium canettii CIPT 140010059, complete genome

Start: 1118979, End: 1119311, Length: 333

Host Lineage: Mycobacterium canettii; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: The Republic of Djibouti, Africa appears to be an exceptional place in terms of tuberculosis (TB) caused by Mycobacterium canettii, a highly unusual tubercle bacillus with unusual smooth colony morphology (STB) related to the M. tuberculosis complex (MTBC). M. canettii was first isolated from a 20-year-old French farmer suffering from pulmonary tuberculosis by G. Canetti in 1969. Since then, this strain has been isolated on rare occasions from patients who lived or were presumably infected in East Africa. It tends to preferentially affect children and foreigners in the Horn of Africa. M. canettii, a possible ancestor of the MTBC, is found almost exclusively in the Horn of Africa where TB is thought to have emerged about 40 000 years ago, coinciding with the expansion of human population out of Africa. The geographical restriction of M. canettii isolates and contrasting genetic diversity are characteristics compatible with a non-human reservoir. With the larger pan-genome reflecting the ancestral, wider gene pool of tubercle bacilli, their lower virulence and faster growth, especially at temperatures below 37 degrees C, plausibly reflecting broader environmental adaptability, STB strains might thus come nearer to the as-yet-unknown missing link between the obligate pathogen M. tuberculosis and environmental mycobacteria (adapted from PMIDs 20831613 and 23291586). Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:1095753:110885911088591109191333Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein1e-35148
NC_009565:1098847:111194011119401112272333Mycobacterium tuberculosis F11, complete genomeconserved serine rich protein1e-35148
NC_012207:1097228:111032211103221110654333Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical serine rich protein1e-35148
NC_000962:1095078:110817211081721108504333Mycobacterium tuberculosis H37Rv, complete genomeCONSERVED HYPOTHETICAL SERINE RICH PROTEIN1e-35148
NC_002945:1095337:110862311086231108955333Mycobacterium bovis AF2122/97, complete genomeputative serine rich protein1e-35148
NC_008769:1125567:113866111386611138993333Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical serine rich protein1e-35148
NC_009525:1096386:110948011094801109812333Mycobacterium tuberculosis H37Ra, complete genomeconserved hypothetical serine rich protein1e-35148
NC_016804:1095846:110894011089401109272333Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein1e-35148
NC_016768:3296478:330017633001763300529354Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein2e-35147
NC_012943:3299744:330344233034423303795354Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein2e-35147
NC_002755:1095105:110821111082111108564354Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein2e-35147
NC_006361:5146000:517326351732635173559297Nocardia farcinica IFM 10152, complete genomehypothetical protein4e-24109
NC_017186:9120711:915325391532539153552300Amycolatopsis mediterranei S699 chromosome, complete genomehypothetical protein6e-2095.9
NC_021064:1789980:181078818107881811084297Propionibacterium avidum 44067, complete genomehypothetical protein8e-1682.4
NC_013174:2163947:216466921646692164872204Jonesia denitrificans DSM 20603, complete genomeregulatory protein, FmdB family4e-1477
NC_018750:3315309:331849333184933318774282Streptomyces venezuelae ATCC 10712, complete genomehypothetical protein7e-1269.3
NC_013525:1953920:196793619679361968187252Thermobaculum terrenum ATCC BAA-798 chromosome 1, complete genomeregulatory protein, FmdB family3e-1167.4
NC_015682:1457004:147401814740181474254237Thermodesulfobacterium sp. OPB45 chromosome, complete genomeFmdB family regulatory protein7e-1062.8
NC_009767:2734166:275094827509482751247300Roseiflexus castenholzii DSM 13941, complete genomeputative regulatory protein, FmdB family1e-0962
NC_014761:1588755:160341316034131603664252Oceanithermus profundus DSM 14977 chromosome, complete genomeregulatory protein, fmdb family2e-0858.2
NC_007912:1173752:117709811770981177334237Saccharophagus degradans 2-40, complete genomehypothetical protein3e-0650.4
NC_014640:6745873:679070167907016791021321Achromobacter xylosoxidans A8 chromosome, complete genomeregulatory protein, FmdB family domain-containing protein 24e-0650.1